Imai et al. show that the light-dependent activation of a proton transporter, Delta-rhodopsin, reverses the pathology caused by the loss of a Parkinson’s disease-associated gene, improving motor behaviors of flies. This study suggests that maintaining the mitochondrial proton-motive force may serve as a therapeutic strategy for Parkinson’s disease.
- Yuzuru Imai
- Tsuyoshi Inoshita
- Nobutaka Hattori
