The exonuclease Apurinic/apyrimidinic endonuclease 1 (APE1) is important for processing matched/mismatched terminus during DNA repair. Here the authors resolve the X-ray crystallography structures of APE1 with varied dsDNAs substrates to assay the nuclease activity.
- Tung-Chang Liu
- Chun-Ting Lin
- Yu-Yuan Hsiao