Chimeric Antigen Receptor (CAR)-T cells show suboptimal efficacy in Acute Myeloid Leukaemia (AML). Here, the authors show that overexpression of C-JUN improves CAR-T cells efficacy in preclinical models for AML and report preliminary results of a pilot phase I clinical trial.
- Shiyu Zuo
- Chuo Li
- Xiaoming Feng
