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Showing 1–8 of 8 results
Advanced filters: Author: Kaj E. Williams Clear advanced filters
  • Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

    • Céline Bellenguez
    • Fahri Küçükali
    • Jean-Charles Lambert
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 412-436
  • Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

    • Itziar de Rojas
    • Sonia Moreno-Grau
    • Agustín Ruiz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16
  • Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.

    • Puya Gharahkhani
    • Eric Jorgenson
    • Janey L. Wiggs
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16
  • The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus.

    • Pradeep Natarajan
    • Akhil Pampana
    • Gina M. Peloso
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14
  • The world faces multiple intersecting crises, several of which are existential. The current dominant economic design is at their root cause, leading to increased advocacy for alternative economic approaches, including Wellbeing Economy. However, the role of culture, both as an objective and as a means of achieving a Wellbeing Economy, is largely absent. In this article, we review how culture has been misunderstood as being dependent on the attainment of basic needs rather than an ever-present, vital, but undervalued attribute of all societies. We discuss how neoliberal economics has individualised and commodified culture, valuing it only as an engine of economic growth and tradeable capital, all of which has led to a substantial diminution and fraying of the social fabric which any positive social transformation will rely upon. Finally, we demonstrate why culture is an essential precondition for the creation of momentum for change through the conversations, shared understandings, new narratives, and communal spaces of all forms which cultural flourishing creates. We conclude by arguing that advocates for a Wellbeing Economy, and similar economic models, such as Doughnut Economics and Foundational Economies, should prioritise and embed support for cultural development as a non-commodified social asset if we are to adequately respond to current crises and navigate to a flourishing and habitable future for ourselves and our descendants.

    • Gerry McCartney
    • Justin O’Connor
    • Kaj Morel
    Comments & OpinionOpen Access
    Humanities and Social Sciences Communications
    Volume: 10, P: 1-5