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Showing 1–5 of 5 results
Advanced filters: Author: Kaleeckal G. Harikumar Clear advanced filters

  • GPCRs can form functionally important dimers. Here, authors study impact of dimerization of the secretin receptor on peptide ligand binding and show high receptor conformational dynamics that facilitate G protein recruitment and activation.

    • Kaleeckal G. Harikumar
    • Sarah J. Piper
    • Laurence J. Miller
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascular disease. Here, authors present a cryo-EM structure and biochemical studies of secretin binding to the SecR:Gs complex which show that interactions between peptide and receptor were dynamic.

    • Maoqing Dong
    • Giuseppe Deganutti
    • Laurence J. Miller
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • A suite of generally applicable methods and tools, developed to enable single-molecule FRET-based studies of transmembrane proteins diffusing in the cell membrane of living cells, was used to study the oligomerization and dynamics of GPCRs.

    • Wesley B. Asher
    • Peter Geggier
    • Jonathan A. Javitch
    Research
    Nature Methods
    Volume: 18, P: 397-405

  • FRET-MD spectrometry reveals atomic-level interfaces involved in oligomerization of the human secretin receptor in live cells, offering mechanistic insights into their quaternary structure and a framework for future application to other GPCRs and membrane proteins.

    • Michael R. Stoneman
    • Thomas D. Killeen
    • Valerică Raicu
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-17