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Showing 1–5 of 5 results
Advanced filters: Author: Kaman Chan Clear advanced filters

  • Mycobacterium tuberculosis virulence is dependent on the secretion system ESX-1. A newly discovered regulator protein termed EspR is described, which positively regulates ESX-1 and is secreted itself, thereby providing a negative feedback regulatory mechanism.

    • Sridharan Raghavan
    • Paolo Manzanillo
    • Jeffery S. Cox
    Research
    Nature
    Volume: 454, P: 717-721

  • The National Cancer Institute (NCI) Genomic Data Commons (GDC) contains more than 2.9 petabytes of genomic and associated clinical data from more than 60 NCI-funded and other contributed cancer genomics research projects. The GDC consists of five applications over a common data model and a common application programming interface.

    • Allison P. Heath
    • Vincent Ferretti
    • Robert L. Grossman
    Comments & Opinion
    Nature Genetics
    Volume: 53, P: 257-262

  • Landgraf et al. developed a chimeric antigen receptor (CAR) platform that functions as a modular system. convertibleTM-T cells are designed to kill antigen-expressing target cells only in the presence of ligands fused to antigen-targeting antibodies (MicAbodyTM). This method provides a wide dosing window while minimizing toxicity.

    • Kyle E. Landgraf
    • Steven R. Williams
    • Kaman Chan Kim
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-13