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Advanced filters: Author: Kamela O. Alegre Clear advanced filters

Structural basis and mechanism of activation of two different families of G proteins by the same GPCR

This study reveals the structural basis for the coupling specificity of one G-protein-coupled receptor, the β₁-adrenergic receptor, to two different families of G proteins. Although the receptor adopts the same conformation, the G proteins have different interaction modes dictated by the overall structure.

Kamela O. Alegre
Navid Paknejad
Xin-Yun Huang
Research10 Nov 2021
Nature Structural & Molecular Biology

Volume: 28, P: 936-944
Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury

A monoclonal antibody that binds NINJ1 and inhibits NINJ1 oligomerization prevents plasma membrane rupture in dying cells, resulting in decreased inflammation of surrounding tissue in mice.

Nobuhiko Kayagaki
Irma B. Stowe
Vishva M. Dixit
ResearchOpen Access17 May 2023
Nature

Volume: 618, P: 1072-1077
Insight into determinants of substrate binding and transport in a multidrug efflux protein

Kamela O. Alegre
Stephanie Paul
Christopher J. Law
ResearchOpen Access10 Mar 2016
Scientific Reports

Volume: 6, P: 1-12

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