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Structure of human drug transporters OATP1B1 and OATP1B3

A key step of drug metabolism in the human body is the uptake into liver cells, which is mediated by transport proteins of the OATP family. Here, authors report cryo-EM structures of two human OATP proteins, providing insight into their function.

Anca-Denise Ciută
Kamil Nosol
Kaspar P. Locher
ResearchOpen Access18 Sept 2023
Nature Communications

Volume: 14, P: 1-13
Phylogeography and colonization pattern of subendemic round-leaved oxeye daisy from the Dinarides to the Carpathians

Kamil Konowalik
ResearchOpen Access30 Sept 2022
Scientific Reports

Volume: 12, P: 1-16
Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP

Hepatitis B and D viruses require docking to the NTCP receptor protein for cell entry, an interaction that can be blocked by the drug bulevirtide. Here the authors use cryo-EM to reveal the structural basis of bulevirtide activity.

Hongtao Liu
Dariusz Zakrzewicz
Kaspar P. Locher
ResearchOpen Access20 Mar 2024
Nature Communications

Volume: 15, P: 1-13
Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

BSEP (ABCB11) is expressed in hepatocytes and extrudes bile salts into the canaliculi of the liver. Here, authors report cryo-EM structures of BSEP providing structural and functional insight into the mechanism of bile salt extrusion and small-molecule inhibition.

Hongtao Liu
Rossitza N. Irobalieva
Kaspar P. Locher
ResearchOpen Access10 Nov 2023
Nature Communications

Volume: 14, P: 1-12
Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry

Human proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce viral infectivity. Here, the authors show that SERINC3 has architecture resembling non-ATP dependent lipid transporters and induces loss of membrane asymmetry correlated with changes in envelope conformation and loss of infectivity.

Susan A. Leonhardt
Michael D. Purdy
Mark Yeager
ResearchOpen Access20 Jul 2023
Nature Communications

Volume: 14, P: 1-16
Structure and mechanism of the ER-based glucosyltransferase ALG6

Analyses reveal a previously undescribed transmembrane protein fold in the endoplasmic reticulum-based glucosyltransferase ALG6 and provide a structural basis for understanding the glucose transfer mechanism.

Joël S. Bloch
Giorgio Pesciullesi
Kaspar P. Locher
Research26 Feb 2020
Nature

Volume: 579, P: 443-447
Structural basis of lipopolysaccharide maturation by the O-antigen ligase

Cryo-electron microscopy structures of the bacterial O-antigen ligase WaaL, combined with genetics, biochemistry and molecular dynamics simulations, provide insight into the mechanism by which WaaL catalyses the biosynthesis of lipopolysaccharide.

Khuram U. Ashraf
Rie Nygaard
Filippo Mancia
Research06 Apr 2022
Nature

Volume: 604, P: 371-376
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

Structural, functional and in silico analyses of the chloroquine-resistance transporter PfCRT of Plasmodium falciparum suggest that distinct mechanistic features mediate the resistance to chloroquine and piperaquine in drug-resistant parasites.

Jonathan Kim
Yong Zi Tan
Filippo Mancia
Research27 Nov 2019
Nature

Volume: 576, P: 315-320
Evaluation metrics and validation of presence-only species distribution models based on distributional maps with varying coverage

Kamil Konowalik
Agata Nosol
ResearchOpen Access15 Jan 2021
Scientific Reports

Volume: 11, P: 1-15
Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver

Hongtao Liu
Rossitza N. Irobalieva
Kaspar P. Locher
CorrespondenceOpen Access20 Jun 2022
Cell Research

Volume: 32, P: 773-776

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Structure of human drug transporters OATP1B1 and OATP1B3

Phylogeography and colonization pattern of subendemic round-leaved oxeye daisy from the Dinarides to the Carpathians

Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP

Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry

Structure and mechanism of the ER-based glucosyltransferase ALG6

Structural basis of lipopolysaccharide maturation by the O-antigen ligase

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

Evaluation metrics and validation of presence-only species distribution models based on distributional maps with varying coverage

Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver

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