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Human Genome Variation (3)
Nature Communications (1)

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Showing 1–4 of 4 results

Advanced filters: Author: Kan Nawata Clear advanced filters

Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis

Cardiac fibrosis is a hallmark of heart failure. Here the authors use single-cell RNA-sequencing, spatial transcriptomics, and genetic manipulations, to show that Htra3 regulates cardiac fibrosis by keeping fibroblasts quiescent and by degrading TGF-beta.

Toshiyuki Ko
Seitaro Nomura
Issei Komuro
ResearchOpen Access07 Jun 2022
Nature Communications

Volume: 13, P: 1-17
Activation of TGF-β signaling in an aortic aneurysm in a patient with Loeys-Dietz syndrome caused by a novel loss-of-function variant of TGFBR1

Hironori Hara
Norifumi Takeda
Issei Komuro
ResearchOpen Access18 Jan 2019
Human Genome Variation

Volume: 6, P: 1-4
A novel mutation of NFIX causes Sotos-like syndrome (Malan syndrome) complicated with thoracic aortic aneurysm and dissection

Tsukasa Oshima
Hironori Hara
Issei Komuro
ResearchOpen Access01 Jun 2017
Human Genome Variation

Volume: 4, P: 1-4
A deleterious MYH11 mutation causing familial thoracic aortic dissection

Norifumi Takeda
Hiroyuki Morita
Issei Komuro
ResearchOpen Access06 Aug 2015
Human Genome Variation

Volume: 2, P: 1-3