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Settling time of a vibrational wavepacket in ionization

Instantaneous generation of a vibrational wavepacket in a molecular ion is usually assumed in an ionization process. Here, by means of frequency-resolved optical gating, the authors observe a non-trivial phase modulation in a H₂⁺molecule, which is interpreted as a ∼1-fs settling time.

Yasuo Nabekawa
Yusuke Furukawa
Katsumi Midorikawa
ResearchOpen Access01 Sept 2015
Nature Communications

Volume: 6, P: 1-6
Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization

DNA hypomethylating agents (HMAs) are used for the treatment of myeloid malignancies, but their therapeutic effects are not satisfactory. Here, the authors show that inhibition of TOPORS, which encodes a ubiquitin E3 ligase, augments the efficacy of HMAs through DNMT1 stabilization.

Satoshi Kaito
Kazumasa Aoyama
Atsushi Iwama
ResearchOpen Access28 Aug 2024
Nature Communications

Volume: 15, P: 1-18
Identification of six new genetic loci associated with atrial fibrillation in the Japanese population

Kaoru Ito, Yoichiro Kamatani, Toshihiro Tanaka and colleagues report a genome-wide association study for atrial fibrillation in the Japanese population. They identify six new loci, five of which are not associated with atrial fibrillation in individuals of European ancestry, suggesting that they may be specific to the Japanese population.

Siew-Kee Low
Atsushi Takahashi
Toshihiro Tanaka
Research17 Apr 2017
Nature Genetics

Volume: 49, P: 953-958
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Synergistic activation of bat SARS-like coronaviruses spike protein by elastase and TMPRSS2

Yuichiro Yamamoto
Tetsuya Inoue
Kohji Noguchi
ResearchOpen Access21 Jul 2025
Scientific Reports

Volume: 15, P: 1-16
Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects

The prediction of mortality due to prostate cancer remains challenging. Here, the authors perform trans-ancestry metaanalysis with a focus on binding sites of the androgen receptor and develop a polygenic risk score.

Shuji Ito
Xiaoxi Liu
Chikashi Terao
ResearchOpen Access23 Aug 2023
Nature Communications

Volume: 14, P: 1-10
Crystal structure of Escherichia coli YidC, a membrane protein chaperone and insertase

Kaoru Kumazaki
Toshiki Kishimoto
Osamu Nureki
ResearchOpen Access03 Dec 2014
Scientific Reports

Volume: 4, P: 1-6
Genetic analysis of right heart structure and function in 40,000 people

Genome-wide analyses of cardiac magnetic resonance imaging data identify loci associated with right heart structure and function. A polygenic predictor of right ventricular ejection fraction is associated with dilated cardiomyopathy risk.

James P. Pirruccello
Paolo Di Achille
Patrick T. Ellinor
Research13 Jun 2022
Nature Genetics

Volume: 54, P: 792-803
Sub-10-fs control of dissociation pathways in the hydrogen molecular ion with a few-pulse attosecond pulse train

Attosecond laser pulses allow to explore the ultrafast atomic or molecular processes occurring in chemical reactions. Here the authors utilize a sequence of two XUV pump-probe pulses to control the dissociation dynamics of the hydrogen molecular ion.

Yasuo Nabekawa
Yusuke Furukawa
Katsumi Midorikawa
ResearchOpen Access20 Sept 2016
Nature Communications

Volume: 7, P: 1-11
Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk

MEGAnE is a new tool to detect and genotype mobile element variants (MEVs) from short-read whole-genome sequencing datasets. Genetic analyses implicate MEVs as population-specific drivers of gene expression variation and disease risk.

Shohei Kojima
Satoshi Koyama
Nicholas F. Parrish
Research11 May 2023
Nature Genetics

Volume: 55, P: 939-951
Structural basis of Sec-independent membrane protein insertion by YidC

The crystal structure of the bacterial protein YidC is reported, together with a structure-based functional analysis, providing insight into the role of YidC in inserting single-spanning membrane proteins into the membrane.

Kaoru Kumazaki
Shinobu Chiba
Osamu Nureki
Research16 Apr 2014
Nature

Volume: 509, P: 516-520
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

The burden of mosaic chromosomal alterations in blood-derived DNA, a type of clonal hematopoiesis, is associated with an increased risk for diverse types of infections, including sepsis and pneumonia.

Seyedeh M. Zekavat
Shu-Hong Lin
Pradeep Natarajan
Research07 Jun 2021
Nature Medicine

Volume: 27, P: 1012-1024
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Population-specific reference panel improves imputation quality for genome-wide association studies conducted on the Japanese population

This study suggests that enhanced imputation quality in genome-wide association studies, using a Japanese population-specific reference panel, leads to the discovery of rare, trait-associated loci.

Jack Flanagan
Xiaoxi Liu
Chikashi Terao
ResearchOpen Access19 Dec 2024
Communications Biology

Volume: 7, P: 1-10
Prognosis of conventional vs. high-frequency ventilation for congenital diaphragmatic hernia: a retrospective cohort study

Makiko Fuyuki
Noriaki Usui
Sasagu Kimura
Research11 Nov 2020
Journal of Perinatology

Volume: 41, P: 814-823
GGT1 is a SNP eQTL gene involved in STAT3 activation and associated with the development of Post-ERCP pancreatitis

Ryutaro Furukawa
Masaki Kuwatani
Masaaki Murakami
ResearchOpen Access28 May 2024
Scientific Reports

Volume: 14, P: 1-10
Charcot–Marie–Tooth disease type 2A with an autosomal-recessive inheritance: the first report of an adult-onset disease

Ryota Hikiami
Hirofumi Yamashita
Ryosuke Takahashi
Research13 Nov 2017
Journal of Human Genetics

Volume: 63, P: 89-92
Erratum: Involvement of hormones in olfactory imprinting and homing in chum salmon

Hiroshi Ueda
Shingo Nakamura
Masahiko Watanabe
Amendments and CorrectionsOpen Access22 Apr 2016
Scientific Reports

Volume: 6, P: 1
Persimmon-derived tannin has antiviral effects and reduces the severity of infection and transmission of SARS-CoV-2 in a Syrian hamster model

Ryutaro Furukawa
Masahiro Kitabatake
Toshihiro Ito
ResearchOpen Access08 Dec 2021
Scientific Reports

Volume: 11, P: 1-11
Involvement of hormones in olfactory imprinting and homing in chum salmon

Hiroshi Ueda
Shingo Nakamura
Masahiko Watanabe
ResearchOpen Access16 Feb 2016
Scientific Reports

Volume: 6, P: 1-13
Frequency-resolved optical gating technique for retrieving the amplitude of a vibrational wavepacket

Yasuo Nabekawa
Yusuke Furukawa
Katsumi Midorikawa
ResearchOpen Access12 Jun 2015
Scientific Reports

Volume: 5, P: 1-14
Protective effect and mechanism of IL-10 on renal ischemia–reperfusion injury

The authors investigated the effects and mechanism of IL-10 in renal ischemia-reperfusion injury (IRI). Compared to wild-type mice with IRI, IL-10 knockout (IL-10 KO) mice with IRI demonstrated decreased renal function, increased mRNA expressions of the pro-inflammatory cytokines, and increased expression of the pro-apoptosis factors. Our findings demonstrate that IL-10 suppresses the production of pro-inflammatory cytokines, renal dysfunction and the expression of pro-apoptosis factors after IRI.

Kenji Sakai
Yuji Nozaki
Itaru Matsumura
Research30 Jan 2019
Laboratory Investigation

Volume: 99, P: 671-683
Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil

Kaoru Ishida
Chie Ito
Satoshi S. Nishizuka
ResearchOpen Access23 May 2017
Scientific Reports

Volume: 7, P: 1-13
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
The pathological role of IL-18Rα in renal ischemia/reperfusion injury

Tomohiro Yano
Yuji Nozaki
Itaru Matsumura
Research20 Oct 2014
Laboratory Investigation

Volume: 95, P: 78-91

Search

Settling time of a vibrational wavepacket in ionization

Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization

Identification of six new genetic loci associated with atrial fibrillation in the Japanese population

DOCK2 is involved in the host genetics and biology of severe COVID-19

Synergistic activation of bat SARS-like coronaviruses spike protein by elastase and TMPRSS2

Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects

Crystal structure of Escherichia coli YidC, a membrane protein chaperone and insertase

Genetic analysis of right heart structure and function in 40,000 people

Sub-10-fs control of dissociation pathways in the hydrogen molecular ion with a few-pulse attosecond pulse train

Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk

Structural basis of Sec-independent membrane protein insertion by YidC

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Population-specific reference panel improves imputation quality for genome-wide association studies conducted on the Japanese population

Prognosis of conventional vs. high-frequency ventilation for congenital diaphragmatic hernia: a retrospective cohort study

GGT1 is a SNP eQTL gene involved in STAT3 activation and associated with the development of Post-ERCP pancreatitis

Charcot–Marie–Tooth disease type 2A with an autosomal-recessive inheritance: the first report of an adult-onset disease

Erratum: Involvement of hormones in olfactory imprinting and homing in chum salmon

Persimmon-derived tannin has antiviral effects and reduces the severity of infection and transmission of SARS-CoV-2 in a Syrian hamster model

Involvement of hormones in olfactory imprinting and homing in chum salmon

Frequency-resolved optical gating technique for retrieving the amplitude of a vibrational wavepacket

Protective effect and mechanism of IL-10 on renal ischemia–reperfusion injury

Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

The pathological role of IL-18Rα in renal ischemia/reperfusion injury

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