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Showing 1–2 of 2 results
Advanced filters: Author: Kaoru Geddes Clear advanced filters

  • T helper type 17 (TH17) responses are crucial for immunity to intestinal pathogens. Here, Stephen E. Girardin, Dana J. Philpott and their colleagues report that early production of IL-17A by enteric CD4+ T helper cells is important for host defense against Citrobacter and Salmonella infection. Induction of IL-17A is dependent on Nod-like receptors. suggesting early, innate TH17 responses are involved in controlling enteric pathogens and may have a role in inflammatory bowel disease.

    • Kaoru Geddes
    • Stephen J Rubino
    • Stephen E Girardin
    Research
    Nature Medicine
    Volume: 17, P: 837-844

  • Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are a family of intracellular sensors that have key roles in innate immunity and inflammation. This Review discusses the effect that research on NLRs will have on vaccination, treatment of chronic inflammatory disorders and acute bacterial infections.

    • Kaoru Geddes
    • João G. Magalhães
    • Stephen E. Girardin
    Reviews
    Nature Reviews Drug Discovery
    Volume: 8, P: 465-479