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Nicotine activates the chemosensory cation channel TRPA1

Topical application of nicotine, as used in nicotine replacement therapies, causes irritation of the mucosa and skin. This reaction had previously been attributed to the activation of nicotinic acetylcholine receptors in chemosensory neurons. However, the Talavera et al. now demonstrate that TRPA1 may be crucial for nicotine-induced irritation.

Karel Talavera
Maarten Gees
Thomas Voets
Research13 Sept 2009
Nature Neuroscience

Volume: 12, P: 1293-1299
TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

Gram-negative bacterial infections can often cause inflammation and pain. Meseguer et al. show that the inflammation and pain result from the direct activation of nociceptor TRPA1 channels by lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria.

Victor Meseguer
Yeranddy A. Alpizar
Félix Viana
ResearchOpen Access20 Jan 2014
Nature Communications

Volume: 5, P: 1-14
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste

Karel Talavera
Keiko Yasumatsu
Bernd Nilius
Research14 Dec 2005
Nature

Volume: 438, P: 1022-1025
TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells

LPS is a major component of gram-negative bacterial cell walls, and triggers immune responses in airway epithelium by activating TLR4. Here the authors show that LPS also activates TRPV4, thereby inducing fast defense responses such as nitric oxide production and increased ciliary beating in mice.

Yeranddy A. Alpizar
Brett Boonen
Karel Talavera
ResearchOpen Access20 Oct 2017
Nature Communications

Volume: 8, P: 1-13
Local immune response to food antigens drives meal-induced abdominal pain

In mice, oral tolerance to food antigens can break down after enteric infection, and this leads to food-induced pain resembling irritable bowel syndrome in humans.

Javier Aguilera-Lizarraga
Morgane V. Florens
Guy E. Boeckxstaens
Research13 Jan 2021
Nature

Volume: 590, P: 151-156
Genomic and immune landscape Of metastatic pheochromocytoma and paraganglioma

The molecular mechanisms underlying metastasis in pheochromocytoma/paraganglioma (mPPGL) remain to be explored. Here, the authors perform genomic and immunogenomic profiling of mPPGL tumors and suggest potential biomarkers for risk of metastasis and immunotherapy response.

Bruna Calsina
Elena Piñeiro-Yáñez
Mercedes Robledo
ResearchOpen Access28 Feb 2023
Nature Communications

Volume: 14, P: 1-20
Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

Steviol glycosides are sweet-tasting compounds isolated from a South American shrub and are increasingly used as sweeteners in foods and beverages. Philippaertet al. demonstrate that steviol glycosides potentiate Ca²⁺-dependent TRPM5 activity and promote glucose-induced insulin secretion and glucose tolerance.

Koenraad Philippaert
Andy Pironet
Rudi Vennekens
ResearchOpen Access31 Mar 2017
Nature Communications

Volume: 8, P: 1-16
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli

Thomas Voets
Grzegorz Owsianik
Bernd Nilius
Research11 Feb 2007
Nature Chemical Biology

Volume: 3, P: 174-182
Differential interactions of bacterial lipopolysaccharides with lipid membranes: implications for TRPA1-mediated chemosensation

Justyna B. Startek
Karel Talavera
Yeranddy A. Alpizar
ResearchOpen Access13 Aug 2018
Scientific Reports

Volume: 8, P: 1-11
Sensing with TRP channels

Thomas Voets
Karel Talavera
Bernd Nilius
Reviews01 Jul 2005
Nature Chemical Biology

Volume: 1, P: 85-92

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