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Showing 1–3 of 3 results
Advanced filters: Author: Karen Funderburk Clear advanced filters

  • Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

    • Jianxin Shi
    • Kouya Shiraishi
    • Qing Lan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • There are more than 20 known melanoma susceptibility genes. Here, using a massively parallel reporter assay, the authors identify risk-associated variants that alter gene transcription, and demonstrate that expression of one such gene, MX2, leads to the promotion of melanoma in a zebrafish model.

    • Jiyeon Choi
    • Tongwu Zhang
    • Kevin M. Brown
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Frida Lona-Durazo et al. perform a GWAS of human hair colour in a Canadian population cohort collected across multiple provinces. By combining these results with transcriptomic and methylation data, the authors provide further insight into the underlying biology of hair colour.

    • Frida Lona-Durazo
    • Marla Mendes
    • Esteban J. Parra
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-12