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Showing 1–2 of 2 results
Advanced filters: Author: Karen Marchillo Clear advanced filters
  • The fungal pathogen Candida auris is resistant to multiple drugs including the common antifungal fluconazole. Here, Iyer et al. identify a compound that potentiates fluconazole activity against C. auris in vitro and in vivo by inhibiting a major efflux pump and thus increasing intracellular fluconazole accumulation.

    • Kali R. Iyer
    • Kaddy Camara
    • Leah E. Cowen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17
  • An amphotericin antifungal that is less toxic to human cells due to its increased capacity for binding the fungal ergosterol over the human cholesterol can still evade resistance mechanisms, challenging the resistance-toxicity yin-yang of antimicrobials.

    • Stephen A Davis
    • Benjamin M Vincent
    • Martin D Burke
    Research
    Nature Chemical Biology
    Volume: 11, P: 481-487