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Showing 1–6 of 6 results
Advanced filters: Author: Karin Miron Clear advanced filters

  • Aberrant oncogene expression can cause replication stress leading to chromosomal breaks. Here the authors map the chromosomal break loci induced by two different oncogenes and by a replication inhibitor, and show that each treatment induces a unique pattern of breaks in the same cell type.

    • Karin Miron
    • Tamar Golan-Lev
    • Batsheva Kerem
    Research
    Nature Communications
    Volume: 6, P: 1-7

  • Common fragile sites are regions susceptible to replication stress and are prone to chromosomal instability. Here, the authors, by analyzing the contribution of 3D chromatin organization, identify and characterize a fragility signature and precisely map these fragility regions.

    • Dan Sarni
    • Takayo Sasaki
    • Batsheva Kerem
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Montserrat Garcia-Closas and colleagues report a meta-analysis of three genome-wide association studies for estrogen receptor (ER)-negative breast cancer, including 4,193 ER-negative breast cancer cases and 35,194 controls, with replication using the iCOGS custom genotyping array in 40 studies, including 6,514 cases and 41,455 controls. They identify four loci associated with ER-negative but not ER-positive breast cancer.

    • Montserrat Garcia-Closas
    • Fergus J Couch
    • Peter Kraft
    Research
    Nature Genetics
    Volume: 45, P: 392-398

  • Douglas Easton and colleagues report a genome-wide association analyses for breast cancer in ~70,000 cases and ~68,000 controls. They identify three new breast cancer susceptibility loci, two of which show association only with estrogen receptor–positive disease.

    • Maya Ghoussaini
    • Olivia Fletcher
    • Douglas F Easton
    Research
    Nature Genetics
    Volume: 44, P: 312-318

  • Over 170 susceptibility loci have been identified by genome-wide association studies in breast cancer. Here, the authors interrogated the role of risk-associated variants from non-breast tissue, and using expression quantitative trait loci, identify potential target genes of known breast cancer susceptibility variants, as well as 11 regions not previously known to be associated with breast cancer risk.

    • Manuel A. Ferreira
    • Eric R. Gamazon
    • Georgia Chenevix-Trench
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18