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Showing 1–4 of 4 results
Advanced filters: Author: Karin Strittmatter Clear advanced filters

  • The blood–brain barrier (BBB) is made up of vascular endothelial cells and was thought to have formed postnatally from astrocytes. Two independent studies demonstrate that this barrier forms during embryogenesis, with pericyte/endothelial cell interactions being critical to regulate the BBB during development. A better understanding of the relationship among pericytes, neuroendothelial cells and astrocytes in BBB function will contribute to our understanding of BBB breakdown during central nervous system injury and disease.

    • Annika Armulik
    • Guillem Genové
    • Christer Betsholtz
    Research
    Nature
    Volume: 468, P: 557-561

  • A study of patients with breast cancer and mouse models demonstrates that most circulating tumour cells are generated during the rest phase of the circadian rhythm, and that these cells are highly prone to metastasize.

    • Zoi Diamantopoulou
    • Francesc Castro-Giner
    • Nicola Aceto
    Research
    Nature
    Volume: 607, P: 156-162

  • How the distal nephron is patterned during kidney development has been difficult to study. Here they show that AP-2β is required for the formation and postnatal function of distal convoluted tubules, whereas AP-2α has a role in maintaining the structure of medullary collecting ducts.

    • Joseph O. Lamontagne
    • Hui Zhang
    • Alexander G. Marneros
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18