Nature Search

The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Meta-analyses in up to 1.3 million individuals identify 87 rare-variant associations with blood pressure traits. On average, rare variants exhibit effects ~8 times larger than the mean effects of common variants and implicate candidate causal genes at associated regions.

Praveen Surendran
Elena V. Feofanova
Joanna M. M. Howson
Research23 Nov 2020
Nature Genetics

Volume: 52, P: 1314-1332
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Mismatch repair deficiency is a rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma

Benjamin Goeppert
Stephanie Roessler
Matthias Kloor
ResearchOpen Access31 Oct 2018
British Journal of Cancer

Volume: 120, P: 109-114
Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Ingrid E Christophersen
Michiel Rienstra
Patrick T Ellinor
Amendments and Corrections27 Jul 2017
Nature Genetics

Volume: 49, P: 1286
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer

An in vivo RNAi dropout screen identifies Mapk14 as a new mediator of sorafenib resistance in hepatocellular carcinoma, and Mapk14 inhibition both improves sorafenib therapy and restores sensitivity to sorafenib-resistant tumors.

Ramona Rudalska
Daniel Dauch
Lars Zender
Research14 Sept 2014
Nature Medicine

Volume: 20, P: 1138-1146
Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents

Some adolescents seek novelty, but it is unknown whether the brain circuits underlying this behaviour can be used to predict later, problematic behaviour. Here, authors show that diminished ventral striatal and prefrontal activity in response to anticipated rewards at age 14 in these individuals predicts problematic drug use at age 16.

Christian Büchel
Jan Peters
Veronika Ziesch
ResearchOpen Access21 Feb 2017
Nature Communications

Volume: 8, P: 1-11
Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Amendments and Corrections26 May 2023
Nature

Volume: 618, P: E19-E20
A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia

Sophie Edtmayer
Agnieszka Witalisz-Siepracka
Dagmar Stoiber
ResearchOpen Access28 May 2024
Cell Death & Disease

Volume: 15, P: 1-12
Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Praveen Surendran
Elena V. Feofanova
Joanna M. M. Howson
Amendments and Corrections16 Mar 2021
Nature Genetics

Volume: 53, P: 762
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Patrick Ellinor and colleagues report meta-analyses of common and rare variant association studies for atrial fibrillation across multiple populations. They identify 12 new loci, some of which implicate genes in atrial electrical and mechanical function.

Ingrid E Christophersen
Michiel Rienstra
Patrick T Ellinor
Research17 Apr 2017
Nature Genetics

Volume: 49, P: 946-952
The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA

Maret Böhm
Kirsty Sawicka
Karl-Heinz Klempnauer
Research31 Jul 2003
Oncogene

Volume: 22, P: 4905-4910
Precision Medicine in Alcohol Dependence: A Controlled Trial Testing Pharmacotherapy Response Among Reward and Relief Drinking Phenotypes

Karl Mann
Corey R Roos
Katie Witkiewitz
Research20 Nov 2017
Neuropsychopharmacology

Volume: 43, P: 891-899
Non-pathogenic Rhizobium radiobacter F4 deploys plant beneficial activity independent of its host Piriformospora indica

Stefanie P Glaeser
Jafargholi Imani
Karl-Heinz Kogel
Research23 Oct 2015
The ISME Journal

Volume: 10, P: 871-884
Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun

Nadja Bitomsky
Maret Böhm
Karl-Heinz Klempnauer
Research30 Aug 2004
Oncogene

Volume: 23, P: 7484-7493
Wilson disease

Wilson disease is an inherited disorder of copper metabolism that is characterized by the pathological accumulation of copper. This Primer describes the pathogenesis of this disorder and outlines diagnostic and management strategies.

Anna Członkowska
Tomasz Litwin
Michael L. Schilsky
Reviews06 Sept 2018
Nature Reviews Disease Primers

Volume: 4, P: 1-20
Prognostic Impact of Carboxylesterase 2 in Cholangiocarcinoma

Benjamin Goeppert
Marcus Renner
Nalân Utku
ResearchOpen Access13 Mar 2019
Scientific Reports

Volume: 9, P: 1-11
Pringle Maneuver in Extended Liver Resection: A propensity score analysis

Mohammed Al-Saeedi
Omid Ghamarnejad
Arianeb Mehrabi
ResearchOpen Access01 Jun 2020
Scientific Reports

Volume: 10, P: 1-10
Modelling of occupational exposure to inhalable nickel compounds

Benjamin Kendzia
Beate Pesch
Thomas Brüning
Research18 Jan 2017
Journal of Exposure Science & Environmental Epidemiology

Volume: 27, P: 427-433

Search

The power of genetic diversity in genome-wide association studies of lipids

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Mapping the human genetic architecture of COVID-19

Mismatch repair deficiency is a rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma

Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

A second update on mapping the human genetic architecture of COVID-19

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer

Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia

Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA

Precision Medicine in Alcohol Dependence: A Controlled Trial Testing Pharmacotherapy Response Among Reward and Relief Drinking Phenotypes

Non-pathogenic Rhizobium radiobacter F4 deploys plant beneficial activity independent of its host Piriformospora indica

Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun

Wilson disease

Prognostic Impact of Carboxylesterase 2 in Cholangiocarcinoma

Pringle Maneuver in Extended Liver Resection: A propensity score analysis

Modelling of occupational exposure to inhalable nickel compounds

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