Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–6 of 6 results
Advanced filters: Author: Karl-Heinz Altmann Clear advanced filters

  • Leucascandrolide A and neopeltolide are structurally related natural products with potent growth inhibitory activity. The synthesis of a designed analog of leucascandrolide A and its evaluation in a yeast haploinsufficiency screen has revealed the cytochrome bc1 complex as a molecular target of these compounds.

    • Karl-Heinz Altmann
    • Erick M Carreira
    News & Views
    Nature Chemical Biology
    Volume: 4, P: 388-389

  • Cryo-EM structures of human ABCG2 bound to synthetic derivatives of inhibitor Ko143 or the multidrug resistance modulator tariquidar together with insight into the structure–activity relationship of the Ko143 scaffold provide a basis for the design of novel ABCG2 inhibitors.

    • Scott M. Jackson
    • Ioannis Manolaridis
    • Kaspar P. Locher
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 333-340

  • Anticancer drugs such as Taxol can affect microtubule dynamics and organization in cells. Direct visualization of the action of such drugs has shown that they can trigger local and cooperative changes in microtubule lattice and induce formation of stable microtubule regions that promote rescues.

    • Ankit Rai
    • Tianyang Liu
    • Anna Akhmanova
    Research
    Nature Materials
    Volume: 19, P: 355-365

  • Microtubule-targeting agents are used successfully as anticancer therapeutics. Here authors develop a fluorescence-anisotropy-based assay to identify and characterize ligands for the maytansine site of tubulin and provide crystal structures of identified ligands in complex with tubulin.

    • Grégory Menchon
    • Andrea E. Prota
    • Michel O. Steinmetz
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9