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Showing 1–10 of 10 results
Advanced filters: Author: Karlene A Cimprich Clear advanced filters

  • Recruiting a hyperactive cytidine deaminase via the guide RNA to dCas9 allows for the introduction of diverse point mutations at the CRISPR target locus to create complex libraries of variants for protein engineering or dissection of protein function.

    • Gaelen T Hess
    • Laure Frésard
    • Michael C Bassik
    Research
    Nature Methods
    Volume: 13, P: 1036-1042

  • The authors develop an EM-based method to directly visualize R-loops. Applying this method to transcription-replication conflicts in human and bacterial cells, they show that DNA:RNA hybrids accumulate primarily behind replication forks, and are linked to fork slowing and fork reversal.

    • Henriette Stoy
    • Katharina Zwicky
    • Massimo Lopes
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 348-359

  • Inappropriate cellular inflammation can cause disease. It emerges that the protein SAMHD1 prevents the release of newly replicated DNA from the nucleus, blocking an undesirable pro-inflammatory response.

    • Madzia P. Crossley
    • Karlene A. Cimprich
    News & Views
    Nature
    Volume: 557, P: 34-35

  • ATR kinase and the related ATM kinase have overlapping but non-redundant functions in the DNA-damage response that maintains genome integrity. ATR signals to regulate DNA replication, cell-cycle transitions and DNA repair through the phosphorylation of various substrates.

    • Karlene A. Cimprich
    • David Cortez
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 9, P: 616-627

  • Defects in DNA replication, or in the pathways evolved to correct DNA replication problems, can cause genomic instability and disease. Zeman and Cimprich discuss recent advances in our understanding of the cellular responses to replication stress.

    • Michelle K. Zeman
    • Karlene A. Cimprich
    Reviews
    Nature Cell Biology
    Volume: 16, P: 2-9

  • RNA–DNA hybrids are immunogenic species that can aberrantly accumulate in the cytoplasm after R-loop processing, linking R-loop accumulation to cell death through the innate immune response.

    • Magdalena P. Crossley
    • Chenlin Song
    • Karlene A. Cimprich
    Research
    Nature
    Volume: 613, P: 187-194

  • Replication stress is controlled by the kinase ataxia telangiectasia and Rad3-related (ATR), which senses and resolves threats to DNA integrity. ATR activation is complex and involves a core set of components that recruit ATR to stressed replication forks, stimulate its kinase activity and amplify downstream signalling to maintain the stability of replication forks.

    • Joshua C. Saldivar
    • David Cortez
    • Karlene A. Cimprich
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 622-636