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Showing 1–4 of 4 results

Advanced filters: Author: Karlyne Reilly Clear advanced filters

Identification of the Notch ligand DLK1 as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma

Adrenocortical carcinoma (ACC) has limited treatment options and few tumor-specific targets. Here the authors report that the Notch ligand DLK1 is highly expressed in ACC acting as a regulator of tumor cell plasticity and chemoresistance, and that DLK1 can be targeted with an antibody drug conjugate.

Nai-Yun Sun
Suresh Kumar
Nitin Roper
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

Karlyne M. Reilly
Dagan A. Loisel
Tyler Jacks
Research01 Sept 2000
Nature Genetics

Volume: 26, P: 109-113
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression

Elevated levels of interleukin-33 have been associated with poor prognosis in patients with glioma. Here the authors show that glioma-derived IL-33 modulates a pro-tumorigenic immune microenvironment by activating resident and recruiting peripheral innate immune cells.

Astrid De Boeck
Bo Young Ahn
Donna L. Senger
ResearchOpen Access05 Oct 2020
Nature Communications

Volume: 11, P: 1-24
Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum

William A Weiss
Mark Israel
Ken Aldape
News & Views18 Oct 2002
Oncogene

Volume: 21, P: 7453-7463

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