Tummino et al. dock 74 million molecules against the human cannabinoid-1 receptor to find uM ligands. Optimization led to a nM agonist conferring analgesia with reduced side effects in mice, highlighting its potential as a pain therapeutic and the promise of a structure-based approach.
- Tia A. Tummino
- Christos Iliopoulos-Tsoutsouvas
- Brian K. Shoichet
