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Showing 1–3 of 3 results
Advanced filters: Author: Karsten Krey Clear advanced filters

  • RNA of some viruses is protected from degradation by a 5′ triphosphate group. Here the authors identify nudix hydrolase 2 (NUDT2) as novel antiviral defense protein that dephosphorylates viral RNA and thereby enables its degradation.

    • Beatrice T. Laudenbach
    • Karsten Krey
    • Andreas Pichlmair
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Multi-omics profiling of monkeypox virus infected human primary cells was used to characterize the infection process and to prioritize potential antiviral drug targets.

    • Yiqi Huang
    • Valter Bergant
    • Andreas Pichlmair
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • This study describes the mechanisms of FOXO1-mediated repression of endoplasmic reticulum (ER) stress in HIV-1 latency. The authors propose a model where inhibition of FOXO1 activity promotes protein accumulation in the ER leading to ER stress signalling and calcium release, which mobilizes ATF4 and NFAT and activates HIV-1 transcription.

    • Albert Vallejo-Gracia
    • Irene P. Chen
    • Melanie Ott
    Research
    Nature Microbiology
    Volume: 5, P: 1144-1157