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Showing 1–8 of 8 results
Advanced filters: Author: Karthik S. Iyer Clear advanced filters
  • Authors measure plasma proteins in a cohort of hospitalised patients presenting to the emergency department with suspected infection, revealing six discrete host response clusters that were driven by pathogen exposure and organ dysfunction, and had distinct clinical characteristics, hospital courses, and responses to treatment.

    • Pratik Sinha
    • Alexandra B. Spicer
    • Matthew M. Churpek
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • Peripherally restricted CB1 inhibitors retain the weight loss benefits of this drug class while sparing the negative psychiatric side effects. The authors here elucidate cryo-EM structures of CB1 bound to peripherally restricted inhibitors to explain these drugs’ molecular mechanism of action.

    • Punita Kumari
    • Szabolcs Dvorácskó
    • Daniel M. Rosenbaum
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13
  • The antiviral drug nirmatrelvir is the active ingredient in Paxlovid, a SARS-CoV-2 Mpro inhibitor developed by Pfizer, however, its synthetic procedure faces limitations for meeting urgent demand. Here, the authors optimize the key synthetic steps and develop a sustainable route to nirmatrelvir in 7 steps and 3 pots with an overall 70% yield.

    • Joseph R. A. Kincaid
    • Juan C. Caravez
    • Bruce H. Lipshutz
    ResearchOpen Access
    Communications Chemistry
    Volume: 5, P: 1-7
  • High-resolution three-dimensional simulations of hydrothermal flow beneath fast-spreading ridges predict two interacting flow components — shallow on-axis flow and deeper off-axis flow — that merge to feed axial vent sites, reconciling previously incompatible models favouring only one flow component.

    • Jörg Hasenclever
    • Sonja Theissen-Krah
    • Colin W. Devey
    Research
    Nature
    Volume: 508, P: 508-512
  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29