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Nature Communications (2)
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Showing 1–4 of 4 results

Advanced filters: Author: Kartikay Sharma Clear advanced filters

Cryo-EM observation of the amyloid key structure of polymorphic TDP-43 amyloid fibrils

This study presents the cryo-EM structures of polymorphic TDP-43-derived amyloid fibrils that share a common fibril protein conformation constituting an amyloid key motif. The obtained results provide a possible mechanistic explanation for the formation of this motif in amyloid fibrils.

Kartikay Sharma
Fabian Stockert
Marcus Fändrich
ResearchOpen Access12 Jan 2024
Nature Communications

Volume: 15, P: 1-8
Cryo-EM structure of a lysozyme-derived amyloid fibril from hereditary amyloidosis

Here the authors perform the reconstruction and analysis of pathological ALys amyloid fibrils extracted from fat tissue from a patient carrying the D87G variant. They reveal an intact amyloid fibril with no evidence of proteolysis and four intact disulphide bonds.

Sara Karimi-Farsijani
Kartikay Sharma
Marcus Fändrich
ResearchOpen Access07 Nov 2024
Nature Communications

Volume: 15, P: 1-9
Using machine learning to determine the time of exposure to infection by a respiratory pathogen

Kartikay Sharma
Manuchehr Aminian
Michael Kirby
ResearchOpen Access01 Apr 2023
Scientific Reports

Volume: 13, P: 1-10
Biomarker selection and a prospective metabolite-based machine learning diagnostic for lyme disease

Eric R. Kehoe
Bryna L. Fitzgerald
Michael J. Kirby
ResearchOpen Access27 Jan 2022
Scientific Reports

Volume: 12, P: 1-14