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Showing 1–5 of 5 results
Advanced filters: Author: Kasey R. Hutt Clear advanced filters

  • In this study, the authors compare the RNA binding patterns of FUS/TLS and TDP-43. Although these proteins regulate the processing of mostly distinct gene products, they do show concurrent regulation of a subset of neuronal transcripts that all have exceptionally long introns.

    • Clotilde Lagier-Tourenne
    • Magdalini Polymenidou
    • Gene W Yeo
    Research
    Nature Neuroscience
    Volume: 15, P: 1488-1497

  • The authors identify brain RNA targets for TDP-43, a RNA binding protein linked to ALS. RNAs derived from genes with very long introns were more affected by TDP-43 levels. TDP-43 also auto-regulated its own synthesis, partly by binding and enhancing the splicing of an intron in its 3′ UTR

    • Magdalini Polymenidou
    • Clotilde Lagier-Tourenne
    • Don W Cleveland
    Research
    Nature Neuroscience
    Volume: 14, P: 459-468

  • MicroRNAs are small RNAs involved in regulation of cognate mRNAs, but predicting their exact targets has been difficult. Using a cross-linking immunoprecipitation technique, a comprehensive examination of endogenous mRNA target sites associated with the C. elegans Argonaute family member ALG-1 is now presented.

    • Dimitrios G Zisoulis
    • Michael T Lovci
    • Gene W Yeo
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 173-179

  • Abnormal functions of RNA-binding proteins TAF15, FUS and TDP43 are associated with amyotrophic lateral sclerosis. Here, Kapeli et al. characterize the RNA targets of TAF15 and identify points of convergence and divergence between the targets of TAF15, FUS and TDP43 in several neuronal systems.

    • Katannya Kapeli
    • Gabriel A. Pratt
    • Gene W. Yeo
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14