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Publisher Correction: MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia

Svetlana S. Itskovich
Arun Gurunathan
Lynn H. Lee
Amendments and CorrectionsOpen Access07 Jul 2020
Nature Communications

Volume: 11, P: 1
Temporal dynamics and genomic programming of plasma cell fates

Singh and colleagues show Tigit controls the generation of germinal center-derived plasma cell precursors that give rise to long-lived differentiated progeny in the bone marrow.

Godhev Kumar Manakkat Vijay
Ming Zhou
Harinder Singh
Research02 May 2024
Nature Immunology

Volume: 25, P: 1097-1109
ThPOK is a critical multifaceted regulator of myeloid lineage development

Basu et al. find that the transcription factor ThPOK is not restricted to T cells, as it also is expressed in myeloid cell progenitors and contributes to the lineage choice of monocyte-dendritic cells as opposed to neutrophils.

Jayati Basu
Andre Olsson
Dietmar J. Kappes
Research20 Jul 2023
Nature Immunology

Volume: 24, P: 1295-1307
Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers

Mammalian skeletal muscle is composed of multinucleated myofibers, containing hundreds of nuclei that coordinate cellular function. Here, the authors show that single-nucleus RNA-sequencing reveals rare and emergent myonuclear populations, and uncovers dynamic transcriptional heterogeneity in development and aging.

Michael J. Petrany
Casey O. Swoboda
Douglas P. Millay
ResearchOpen Access11 Dec 2020
Nature Communications

Volume: 11, P: 1-12
Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies

Mutations in the splicing factor RBM20 cause aggressive Dilated Cardiomyopathy. Here the authors generated RBM20 R636S mutants and knockout in human iPSC-derived cardiomyocytes. Mutant RBM20 showed different target RNA binding, altered splicing and localization to cytoplasmic processing bodies.

Aidan M. Fenix
Yuichiro Miyaoka
Nathan Salomonis
ResearchOpen Access03 Nov 2021
Nature Communications

Volume: 12, P: 1-14
Mouse models of neutropenia reveal progenitor-stage-specific defects

Mouse models of severe congenital neutropenia using patient-derived mutations in the GFI1 locus are used to determine the mechanisms by which the disease progresses.

David E. Muench
Andre Olsson
H. Leighton Grimes
Research22 Apr 2020
Nature

Volume: 582, P: 109-114
MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia

The alternative splicing regulator MBNL1 is overexpressed in MLL-rearranged leukaemia. Here, the authors show that MBNL1-mediated alternative splicing leads to a specific splicing profile in MLL-rearranged leukaemia and loss or inhibition of MBNL1 impairs leukaemia development in vitro and in vivo.

Svetlana S. Itskovich
Arun Gurunathan
Lynn H. Lee
ResearchOpen Access12 May 2020
Nature Communications

Volume: 11, P: 1-14
Brain motor and fear circuits regulate leukocytes during acute stress

Distinct brain regions differentially and rapidly tailor the leukocyte landscape during psychological stress, calibrating the ability of the immune system to respond to physical threats.

Wolfram C. Poller
Jeffrey Downey
Filip K. Swirski
Research30 May 2022
Nature

Volume: 607, P: 578-584
Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis

Human induced pluripotent stem cell derived cardiomyocytes are a powerful model for cardiogenesis and disease in vitro. Here the authors comprehensively map cardiac differentiation using multiple modalities, including single-cell RNA seq and CyTOF, in cells with a gain or loss of function in key cardiac transcription factors.

Jared M. Churko
Priyanka Garg
Joseph C. Wu
ResearchOpen Access21 Nov 2018
Nature Communications

Volume: 9, P: 1-14
Defective transcription elongation in a subset of cancers confers immunotherapy resistance

Transcription elongation (TE) is a key point of inducible gene expression regulation. Here, the authors report widespread TE defects (TE^deff) in a high proportion of cancers that correlate with poor immunotherapy response, highlighting TE defects as potential routes for immune resistance.

Vishnu Modur
Navneet Singh
Kakajan Komurov
ResearchOpen Access23 Oct 2018
Nature Communications

Volume: 9, P: 1-15
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity

Linking transcription factors with disease loci implicates EBNA2, encoded by Epstein–Barr virus, in autoimmune diseases. Applying the method more widely identifies associations for hundreds of transcription factors, illuminating disease mechanisms.

John B. Harley
Xiaoting Chen
Matthew T. Weirauch
Research16 Apr 2018
Nature Genetics

Volume: 50, P: 699-707
A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation

Courtney M. Jackson
Martin Demmert
Claire A. Chougnet
ResearchOpen Access21 Mar 2022
Mucosal Immunology

Volume: 15, P: 730-744

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