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Showing 1–9 of 9 results
Advanced filters: Author: Kashyap Dave Clear advanced filters

  • The E2F family of transcription factors controls many important cellular processes. Here, the authors determine the structure of an atypical E2F that contains two DNA binding domains, and propose a mechanism of action for these atypical E2Fs.

    • Ekaterina Morgunova
    • Yimeng Yin
    • Jussi Taipale
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • Analysis of massively parallel reporter assays measuring the transcriptional activity of DNA sequences indicates that most transcription factor (TF) activity is additive and does not rely on specific TF–TF interactions. Individual TFs can have different gene regulatory activities.

    • Biswajyoti Sahu
    • Tuomo Hartonen
    • Jussi Taipale
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 283-294

  • Lysosomal storage diseases like mucopolysaccharidosis type I (MPS I) cause pathology before birth and result in early morbidity and mortality. Here, the authors show that in utero base editing mediates multi-organ phenotypic and survival benefits in a mouse model recapitulating a common human MPSI mutation.

    • Sourav K. Bose
    • Brandon M. White
    • William H. Peranteau
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Lauri Aaltonen, Jussi Taipale and colleagues report frequent mutation of CTCF- and cohesin-binding sites (CBSs) in multiple cancer types. They find that the frequency of CBS mutations in microsatellite-stable colorectal cancer is 1.5 times higher than that of other known cancer mutational targets.

    • Riku Katainen
    • Kashyap Dave
    • Lauri A Aaltonen
    Research
    Nature Genetics
    Volume: 47, P: 818-821

  • In this study the authors examine the allelic imbalance (AI) landscape of colorectal cancer, reporting loss of TP53 as a driver of AI. They use CRISPR-Cas9 screens to identify 79 genes (within AI regions) regulating cell growth and identify a network of transcription factors that may contribute to colorectal tumorigenesis.

    • Kimmo Palin
    • Esa Pitkänen
    • Lauri A. Aaltonen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • The rich ethnolinguistic and sociocultural differences that exist in India offers a unique opportunity to study human diversity. With the whole genomes of 10,000 healthy and unrelated Indians from 83 populations, the GenomeIndia project captures the genetic diversity of one of the highly underrepresented populations in the global genomics landscape.

    • Chandrika Bhattacharyya
    • Krithika Subramanian
    • Bratati Kahali
    Comments & Opinion
    Nature Genetics
    Volume: 57, P: 767-773

  • A high-throughput analysis of DNA binding in over 9,000 interacting transcription factor pairs reveals that the interactions are often actively mediated by the DNA itself and the composite DNA sites recognized are different from the individual motifs of each transcription factor.

    • Arttu Jolma
    • Yimeng Yin
    • Jussi Taipale
    Research
    Nature
    Volume: 527, P: 384-388