Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–14 of 14 results
Advanced filters: Author: Kasper D Rand Clear advanced filters

  • The identification of top spatially variable genes is a key step in the analysis of spatially-resolved transcriptomics data. Here, the authors develop a scalable method based on nearest-neighbor Gaussian processes and evaluate performance compared to existing and baseline methods.

    • Lukas M. Weber
    • Arkajyoti Saha
    • Stephanie C. Hicks
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • The serotonin transporter (SERT) is responsible for re-uptake of serotonin into the presynaptic neuron and plays a key role in synaptic transmission. Here, the authors use hydrogen-deuterium exchange mass spectrometry to probe the conformational dynamics of human SERT in the absence and presence of known substrates and targeted drugs.

    • Ingvar R. Möller
    • Marika Slivacka
    • Kasper D. Rand
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • The dopamine transporter is responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Here authors use hydrogen-deuterium exchange mass spectrometry to monitor Na+- and dopamine-induced conformational dynamics of the dopamine transporter.

    • Anne Kathrine Nielsen
    • Ingvar R. Möller
    • Claus J. Loland
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • The dopamine transporter, DAT, controls dopamine signaling by facilitating its reuptake using the Na+ gradient as driving force. Here, the authors uncover that an antiport of K+ ions also contributes to setting the rate of DAT-mediated dopamine clearance.

    • Solveig G. Schmidt
    • Mette Galsgaard Malle
    • Claus J. Loland
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Attachment of human noroviruses to histo blood group antigens (HBGAs) is essential for infection. Here the authors report that an asparagine residue located near the HBGA-attachment site can convert into an iso-aspartate residue through spontaneous deamidation and influence HBGA recognition.

    • Alvaro Mallagaray
    • Robert Creutznacher
    • Thomas Peters
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Calvaresi et al. use hydrogen-deuterium exchange coupled to mass spectrometry to compare the conformational dynamics of the human heat shock protein Hsp70 when free and when associated with liposomes composed of common lysosomal lipids. They also investigate the conformational changes occuring in Hsp70 when transitioning from the pH of the cytosol to that of early and late lysosomes. This study provides new molecular insights into how Hsp70 can stabilize endo-lysosomal membranes and inhibit the uncontrolled release of degradative enzymes linked to lysosomal storage disorders.

    • Valeria Calvaresi
    • Line T. Truelsen
    • Kasper D. Rand
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11

  • Nilsen et al. show that structural alterations in the last C-terminal α-helix of albumin strongly reduce its binding to the neonatal Fc receptor, decreasing the half-life of albumin in humans. This study suggests the structural requirement of the C-terminal of albumin for its long plasma half-life, providing insights into the design of albumin used to carry drugs.

    • Jeannette Nilsen
    • Esben Trabjerg
    • Jan Terje Andersen
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-11

  • The SSP–RCP scenario framework has been an important component of physical, social and integrated climate change research for the past decade. This Perspective reviews the successes of the framework and the challenges it faces, and provides suggestions for improvement moving forward.

    • Brian C. O’Neill
    • Timothy R. Carter
    • Ramon Pichs-Madruga
    Reviews
    Nature Climate Change
    Volume: 10, P: 1074-1084