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Showing 1–4 of 4 results
Advanced filters: Author: Katelynn R. Kazane Clear advanced filters

  • Plasmacytoid dendritic cells (pDC) are the major IFN-I-producing cells, but this production returns to baseline soon after viral infection. Here the authors show that this decrease in IFN-I production and related pDC functions may be attributed to suppressed oxidative and glycolytic metabolism of pDCs, with lactate dehydrogenase B identified as a regulator.

    • Trever T. Greene
    • Yeara Jo
    • Elina I. Zúñiga
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • A coupled knockdown-editing screen shows that CRISPR–Cas9 editing in human cells requires the Fanconi anemia pathway, which acts by diverting double-strand break repair away from non-homologous end joining toward single-strand template repair.

    • Chris D. Richardson
    • Katelynn R. Kazane
    • Jacob E. Corn
    Research
    Nature Genetics
    Volume: 50, P: 1132-1139

  • Altering cellular responses to double-strand breaks in DNA could rebalance CRISPRediting outcomes. Here, the authors use a pooled CRISPR screen to identify inhibition of CDC7 as a strategy to improve HDR outcomes.

    • Beeke Wienert
    • David N. Nguyen
    • Jacob E. Corn
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • High-resolution contact maps of active enhancers and target genes generated by H3K27ac HiChIP in primary human cells provide rational guides to link noncoding disease-associated risk variants to candidate causal genes. Genes are validated by CRISPR activation and interference at connected enhancers and eQTL analysis, leading to a fourfold increase in the number of potential target genes for autoimmune and cardiovascular diseases.

    • Maxwell R Mumbach
    • Ansuman T Satpathy
    • Howard Y Chang
    Research
    Nature Genetics
    Volume: 49, P: 1602-1612