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Showing 1–2 of 2 results
Advanced filters: Author: Katherine E. Gadek Clear advanced filters

  • Histologically, PAX3-FOXO1 (P3F) fusion-positive rhabdomyosarcoma (FP-RMS) resembles muscles cells, however, its cell-of-origin is less clear. Here, the authors demonstrate that P3F expression induces endothelial cells reprogramming into functional myogenic stem cells, driving the formation of FP-RMS in mouse models.

    • Madeline B. Searcy
    • Randolph K. Larsen IV
    • Mark E. Hatley
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-23

  • PTEN copy number loss is found in 25% of fusion-negative rhabdomyosarcomas (FN-RMS). Here, the authors use a Hedgehog-driven FN-RMS mouse model to show that PTEN loss drives the expression of core transcription factor PAX7 and its transcriptional axis, which determines FN-RMS tumour identity.

    • Casey G. Langdon
    • Katherine E. Gadek
    • Mark E. Hatley
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18