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Showing 1–2 of 2 results
Advanced filters: Author: Katherine Minjee Chung Clear advanced filters

  • Using mosaic analysis with double markers to label genetically-distinct clones in established tumors, the authors studied the effects of p53 loss in lung and pancreatic cancers. They find that loss of p53 enhances progression in both models but only influences initiation in the pancreas.

    • Mandar Deepak Muzumdar
    • Kimberly Judith Dorans
    • Tyler Jacks
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Pancreatic cancer cells may develop resistance to KRAS inhibitors due to activation of compensatory pathways. In this study, the authors demonstrate that KRAS is dispensable in a subset of pancreatic cancer and that PI3K signalling may have an important role in mediating tumor growth following KRAS inhibition.

    • Mandar Deepak Muzumdar
    • Pan-Yu Chen
    • Tyler Jacks
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19