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Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation

Xin et al. show, through intravital imaging, that Kras^G12D induces epithelial tissue deformation in a spatiotemporally specific manner by converting the pulsatile ERK signal fluctuation in stem cells into sustained activation.

Tianchi Xin
Sara Gallini
Valentina Greco
Research30 Apr 2024
Nature Cell Biology

Volume: 26, P: 859-867
Injury prevents Ras mutant cell expansion in mosaic skin

Following skin injury, wild-type epithelial cells outcompete oncogenic Ras G12V mutant cells owing to differential activation of the EGFR signalling pathway during injury repair.

Sara Gallini
Karl Annusver
Valentina Greco
ResearchOpen Access21 Jun 2023
Nature

Volume: 619, P: 167-175
Correction of aberrant growth preserves tissue homeostasis

Intravital imaging reveals unanticipated plasticity of adult skin epithelium in mice when faced with mutational or non-mutational insults, and elucidates the dynamic cellular behaviours used for its return to a homeostatic state.

Samara Brown
Cristiana M. Pineda
Valentina Greco
Research02 Aug 2017
Nature

Volume: 548, P: 334-337