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Showing 1–2 of 2 results
Advanced filters: Author: Kathrin Julia Laue Clear advanced filters

  • Despite being a hallmark of cancer, the identification of targetable vulnerabilities of aneuploid cancer cells remains limited. Here, the authors develop RPE1-hTERT cell lines with varying degrees of aneuploidy to investigate the consequences of chromosomal imbalance, identifying CRAF as an aneuploid-selective therapeutically targetable vulnerability.

    • Johanna Zerbib
    • Marica Rosaria Ippolito
    • Stefano Santaguida
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Fendt and colleagues find that pre-metastatic niche formation and a high-fat diet increase palmitate availability in future organs of metastases and show that breast cancer cells use palmitate to generate acetyl-CoA, acetylate the NF-κB subunit p65 and induce pro-metastatic signaling.

    • Patricia Altea-Manzano
    • Ginevra Doglioni
    • Sarah-Maria Fendt
    Research
    Nature Cancer
    Volume: 4, P: 344-364