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Showing 1–8 of 8 results

Advanced filters: Author: Kathrin Landgraf Clear advanced filters

Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity

A mutation leading to ubiquitous ectopic expression of agouti signaling protein, which is not picked up in conventional genetic screenings, is reported in patients with severe childhood obesity.

Elena Kempf
Kathrin Landgraf
Antje Körner
ResearchOpen Access19 Dec 2022
Nature Metabolism

Volume: 4, P: 1697-1712
Cell-selective labelling of proteomes in Drosophila melanogaster

Mutated tRNA synthetases can incorporate non-canonical amino acids into proteins. Erdmann et al. exploit this property to metabolically label newly synthesized proteins in selected cell types in Drosophila, and demonstrate their detection using proteomics (BONCAT) and fluorescence imaging (FUNCAT).

Ines Erdmann
Kathrin Marter
Daniela C. Dieterich
ResearchOpen Access03 Jul 2015
Nature Communications

Volume: 6, P: 1-11
Mitochondrial RNA stimulates beige adipocyte development in young mice

Hoang et al. show that mitochondrial RNA in young beige adipocytes triggers mitobiogenesis and thermogenesis, while an interferon response is avoided through vitamin D-mediated suppression of IRF7 expression.

Anh Cuong Hoang
László Sasi-Szabó
Tamás Röszer
ResearchOpen Access28 Nov 2022
Nature Metabolism

Volume: 4, P: 1684-1696
Independent phenotypic plasticity axes define distinct obesity sub-types

Yang et al. show that neuronatin (NNAT) can explain part of the phenotypic variation of complex traits, independently of genetics or the environment. Such NNAT-dependent variations can stratify human cohorts into four metabolic sub-types, including two distinct types of obesity.

Chih-Hsiang Yang
Luca Fagnocchi
J. Andrew Pospisilik
ResearchOpen Access12 Sept 2022
Nature Metabolism

Volume: 4, P: 1150-1165
FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis

Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue. Here the authors show that FGF6 and FGF9 induce UCP1 expression in adipocytes and preadipocytes, via modulation of a transcriptional network that is dissociated from brown adipogenesis.

Farnaz Shamsi
Ruidan Xue
Yu-Hua Tseng
ResearchOpen Access17 Mar 2020
Nature Communications

Volume: 11, P: 1-16
Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity

André Nguyen Dietzsch
Hadi Al-Hasani
Simone Prömel
ResearchOpen Access26 Apr 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-14
Macrophages in obesity are characterised by increased IL-1β response to calcium-sensing receptor signals

Stephan Thrum
Miriam Sommer
Ulf Wagner
ResearchOpen Access05 Aug 2022
International Journal of Obesity

Volume: 46, P: 1883-1891
The repertoire of Adhesion G protein-coupled receptors in adipocytes and their functional relevance

Tomáš Suchý
Christian Zieschang
Doreen Thor
ResearchOpen Access19 Mar 2020
International Journal of Obesity

Volume: 44, P: 2124-2136