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TCR signal strength controls thymic differentiation of iNKT cell subsets

Invariant natural killer T (iNKT) cells can be subsetted by their cytokine profiles, but how they develop in the thymus is unclear. Here the authors show, by analysing mice carrying mutant Zap70 genes, that T cell receptor signaling strength induces epigenetic changes of genes to modulate iNKT lineages.

Kathryn D. Tuttle
S. Harsha Krovi
Laurent Gapin
ResearchOpen Access09 Jul 2018
Nature Communications

Volume: 9, P: 1-13
Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model

A mouse model of Down syndrome (DS) highlights the importance of triplication of the IFNR gene cluster for a variety of DS-associated traits. Copy number correction resulted in amelioration of multiple phenotypes associated with the condition.

Katherine A. Waugh
Ross Minter
Joaquin M. Espinosa
ResearchOpen Access05 Jun 2023
Nature Genetics

Volume: 55, P: 1034-1047
Extracellular matrix deposition precedes muscle-tendon integration during murine forelimb morphogenesis

The authors show that the muscle-tendon unit is established independently of muscle in the developing mouse forelimb; however, muscle is needed for the proper assembly of the extracellular matrix at the myotendinous junction.

Yue Leng
Sarah N. Lipp
Sarah Calve
ResearchOpen Access12 Aug 2025
Communications Biology

Volume: 8, P: 1-12
Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

Down syndrome (DS) is caused by trisomy 21 (T21), but the underlying etiology of the related immune and neurological dysfunction is unclear. Here, the authors show that T21 activates the kynurenine pathway via increased interferon receptor copy number, which could contribute to DS pathophysiology.

Rani K. Powers
Rachel Culp-Hill
Joaquin M. Espinosa
ResearchOpen Access18 Oct 2019
Nature Communications

Volume: 10, P: 1-11
T cell receptor recognition of CD1b presenting a mycobacterial glycolipid

Germline-encoded mycolyl lipid-reactive (GEM) T cells recognize CD1b proteins presenting mycobacterial mycolates via their T-cell receptors (TCRs). Here, the authors present the structure of this interaction and provide a molecular basis for the co-recognition of CD1b and a mycobacterial glycolipid.

Stephanie Gras
Ildiko Van Rhijn
Jamie Rossjohn
ResearchOpen Access27 Oct 2016
Nature Communications

Volume: 7, P: 1-12
Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice

Jingjing Zhang
Romain Bedel
Jennifer L. Matsuda
ResearchOpen Access03 Jun 2016
Scientific Reports

Volume: 6, P: 1-10
Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

α-synuclein amyloid fibrils are associated with Parkinson's disease. SSNMR analyses now reveal the atomic structure of a pathogenic human α-synuclein fibril, providing a framework for understanding fibril nucleation, propagation and interactions with small molecules.

Marcus D Tuttle
Gemma Comellas
Chad M Rienstra
Research28 Mar 2016
Nature Structural & Molecular Biology

Volume: 23, P: 409-415
Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse model

Jessica A. Jiménez
Jeremy M. Simon
Mark J. Zylka
ResearchOpen Access01 Apr 2022
Scientific Reports

Volume: 12, P: 1-15

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TCR signal strength controls thymic differentiation of iNKT cell subsets

Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model

Extracellular matrix deposition precedes muscle-tendon integration during murine forelimb morphogenesis

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

T cell receptor recognition of CD1b presenting a mycobacterial glycolipid

Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse model

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