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Showing 1–1 of 1 results
Advanced filters: Author: Katrin B. Ishii-Schrade Clear advanced filters

  • Mucin 21 (MUC21) is a large glycoprotein that protects squamous epithelia. Glycan changes in mucins occur in cancer cells and are thought to contribute to malignant progression. We report glycoform-dependent antiapoptotic effects of MUC21. Various MUC21 glycoforms were expressed in HEK293 and CHO cells. Apoptosis was induced using etoposide or UV exposure. MUC21 with glycans terminated with galactose/sialic acid inhibited apoptosis; MUC21 with no glycans or N-acetylgalactoseamine did not.

    • Yuan Tian
    • Kaori Denda-Nagai
    • Tatsuro Irimura
    ResearchOpen Access
    Cell Death Discovery
    Volume: 8, P: 1-12