The mechanisms controlling excessive inflammatory responses, which can result in damage to tissues and diseases such as arthritis and type-2 diabetes, are poorly understood. Mouse effector and memory CD4+ T cells are now shown to inhibit inflammasome activity, revealing a mechanism by which effector and memory T cells can suppress potentially damaging inflammation while leaving the primary inflammatory response intact.
- Greta Guarda
- Catherine Dostert
- Jürg Tschopp
