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Showing 1–2 of 2 results
Advanced filters: Author: Katrin Meissl Clear advanced filters

  • Bock and colleagues perform integrative analysis of JAK-STAT mutant mice and find JAK-STAT signaling regulates CD8+ T cell and macrophage homeostasis by contributing to a poised epigenetic and transcription-regulatory state, preparing cells to rapidly respond to stimuli.

    • Nikolaus Fortelny
    • Matthias Farlik
    • Christoph Bock
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 847-859

  • Pyruvate dehydrogenase (PDH) is identified as a crucial mediator of BRAFV600E-induced cellular senescence: PDH is activated by BRAF-mediated suppression of PDK1, enhancing oxidative glucose metabolism, and PDK1 depletion eradicates mutant BRAF melanomas, indicating that this relationship between cell senescence and metabolism might be exploited therapeutically.

    • Joanna Kaplon
    • Liang Zheng
    • Daniel S. Peeper
    Research
    Nature
    Volume: 498, P: 109-112