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Showing 1–8 of 8 results
Advanced filters: Author: Kavitha Sarma Clear advanced filters

  • R-loops are three-stranded nucleic acid structures that contribute to genome instability and accumulate in neurological diseases. Here the authors identify R-loop proximal factors, which are enriched for zinc finger and homeodomain proteins, including activity-dependent neuroprotective protein (ADNP). ADNP plays a role in R-loop resolution and loss-of-function leads to R-loop accumulation.

    • Qingqing Yan
    • Phillip Wulfridge
    • Kavitha Sarma
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • The DCAF15 E3 ubiquitin ligase is targeted by aryl-sulfonamide molecular glues leading to neo-substrate proteasomal degradation. Here, the authors reveal DCAF15 as a cell autonomous acute myeloid leukemia dependency sustaining proliferation through control of cohesin complex recycling dynamics.

    • Grant P. Grothusen
    • Renxu Chang
    • Luca Busino
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of PRC2 to a subset of polycomb targets.

    • Wenqing Ren
    • Nicole Medeiros
    • Kavitha Sarma
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can inhibit growth in CARM1 expressing ovarian cancers.

    • Jianhuang Lin
    • Heng Liu
    • Rugang Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Shukla, Samaniego-Castruita and colleagues show that loss of TET methylcytosine dioxygenases in B cells is associated with increased DNA–RNA hybrids and G-quadruplex DNA structures in parallel with genomic instability and development of germinal center-derived lymphomas.

    • Vipul Shukla
    • Daniela Samaniego-Castruita
    • Anjana Rao
    Research
    Nature Immunology
    Volume: 23, P: 99-108

  • During mammalian X-chromosome inactivation, the Xist long noncoding RNA coats the future inactive X chromosome and recruits polycomb repressive complex 2 to a nucleation site, but how Xist spreads silencing across the entire X chromosome is unclear; here high-resolution maps of Xist binding sites across the X chromosome are generated and show that Xist does not spread across the inactive X chromosome uniformly but in two steps, initially targeting gene-rich islands before later spreading to intervening gene-poor domains.

    • Matthew D. Simon
    • Stefan F. Pinter
    • Jeannie T. Lee
    Research
    Nature
    Volume: 504, P: 465-469