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Showing 1–5 of 5 results
Advanced filters: Author: Kaycie Deyle Clear advanced filters

  • Inhibiting thrombosis without inducing bleeding is a major challenge for anticoagulant agents. Here the authors describe a synthetic FXIIa inhibitor able to efficiently prevent thrombosis in mice and suppress coagulation in artificial lungs in rabbits without increasing the risk of bleeding.

    • Jonas Wilbs
    • Xu-Dong Kong
    • Christian Heinis
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • A major challenge for the application of peptide therapeutics is their short half-lifein vivo. Here, the authors design peptide-fatty acid chimeras bearing an engineered linker that promotes albumin binding and allows longer circulation times of therapeutic peptides in animal models.

    • Alessandro Zorzi
    • Simon J. Middendorp
    • Christian Heinis
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Crosslinking within peptides containing two pairs of cysteines to form chemical bridges has now been shown to provide rapid access to thousands of different macrocyclic scaffolds in libraries that are easy to synthesize, screen and decode. Applying this strategy to phage-encoded libraries yielded binders with remarkable affinities despite the small molecular mass.

    • Sangram S. Kale
    • Camille Villequey
    • Christian Heinis
    Research
    Nature Chemistry
    Volume: 10, P: 715-723

  • It is difficult to develop a selective ligand for point mutations in proteins that are not found in easily addressable locations. Now, an all-chemical, epitope-targeting strategy has been reported, and was used to discover an inhibitory peptide with selectivity for the E17K point mutation in the PH Domain of the Akt1 oncoprotein.

    • Kaycie M. Deyle
    • Blake Farrow
    • James R. Heath
    Research
    Nature Chemistry
    Volume: 7, P: 455-462