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Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies

Variants in the PSMC5 gene impair proteasome function and cellular homeostasis, altering brain development in children. This study reveals underlying molecular mechanisms contributing to this neurodevelopmental phenotype, and suggests therapeutic leads for neurodevelopmental proteasomopathies.

Sébastien Küry
Janelle E. Stanton
Elke Krüger
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-21
A parabrachial hub for need-state control of enduring pain

Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.

Nitsan Goldstein
Amadeus Maes
J. Nicholas Betley
ResearchOpen Access08 Oct 2025
Nature

Volume: 647, P: 689-697
Microglia regulate motor neuron plasticity via reciprocal fractalkine and adenosine signaling

The role of microglia in regulating spinal neuroplasticity is unknown. Here, the authors show that spinal microglia regulate plasticity in motor neurons that drive breathing through reciprocal fractalkine and adenosine signaling.

Alexandria B. Marciante
Arash Tadjalli
Gordon S. Mitchell
ResearchOpen Access28 Nov 2024
Nature Communications

Volume: 15, P: 1-16
A dual-pathway architecture for stress to disrupt agency and promote habit

Adaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain pathway needed for agency and activating one that promotes habit.

Jacqueline R. Giovanniello
Natalie Paredes
Kate M. Wassum
Research19 Feb 2025
Nature

Volume: 640, P: 722-731
A diencephalic circuit in rats for opioid analgesia but not positive reinforcement

Opioids are potent analgesics but also have addiction risk. Here a lateral preoptic area to lateral habenula connection is identified by which opioids relieve ongoing pain but do not produce reward in animals that do not have ongoing pain.

Maggie W. Waung
Kayla A. Maanum
Elyssa B. Margolis
ResearchOpen Access09 Feb 2022
Nature Communications

Volume: 13, P: 1-13
NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice

Circulating monocytes contribute to the transition to pain chronicity but the molecular events that cause their deployment are still unclear. Using a mouse model of hyperalgesic priming, here the authors show that blood monocytes contribute to the emergence of chronic pain via a mechanism that requires a transient disruption of NAAA-regulated lipid signaling.

Yannick Fotio
Alex Mabou Tagne
Daniele Piomelli
ResearchOpen Access24 Feb 2024
Nature Communications

Volume: 15, P: 1-15
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Germline Elongator mutations in Sonic Hedgehog medulloblastoma

Germline mutations in the Elongator complex gene ELP1 predispose individuals to the development of childhood medulloblastoma.

Sebastian M. Waszak
Giles W, Robinson
Stefan M. Pfister
Research01 Apr 2020
Nature

Volume: 580, P: 396-401
Development and validation of a high throughput SARS-CoV-2 whole genome sequencing workflow in a clinical laboratory

Sun Hee Rosenthal
Anna Gerasimova
Felicitas Lacbawan
ResearchOpen Access08 Feb 2022
Scientific Reports

Volume: 12, P: 1-12
Impact of the COVID-19 nonpharmaceutical interventions on influenza and other respiratory viral infections in New Zealand

New Zealand has been relatively successful in controlling COVID-19 due to implementation of strict non-pharmaceutical interventions. Here, the authors demonstrate a striking decline in reports of influenza and other non-influenza respiratory pathogens over winter months in which the interventions have been in place.

Q. Sue Huang
Tim Wood
Richard J. Webby
ResearchOpen Access12 Feb 2021
Nature Communications

Volume: 12, P: 1-7
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
Defining a research agenda for environmental wastewater surveillance of pathogens

Alexander G. Shaw
Catherine Troman
Julia Fitzner
Correspondence03 Aug 2023
Nature Medicine

Volume: 29, P: 2155-2157
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling: role of the ubiquitin proteasome system

Anil K. Singh
Mahamudul Haque
Salahuddin Ahmed
Research11 Sept 2019
Cellular & Molecular Immunology

Volume: 18, P: 162-170
Childhood nephrotic syndrome and the clinical profile of thromboembolism: a systematic review and meta-analysis

Kayla Dadgar
Yuanxin Xue
Rahul Chanchlani
Reviews20 Sept 2022
Pediatric Research

Volume: 93, P: 1463-1469
Assessing non-Mendelian inheritance in inherited axonopathies

Dana M. Bis-Brewer
Ziv Gan-Or
Stephan Züchner
Research03 Aug 2020
Genetics in Medicine

Volume: 22, P: 2114-2119

Search

Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies

A parabrachial hub for need-state control of enduring pain

Microglia regulate motor neuron plasticity via reciprocal fractalkine and adenosine signaling

A dual-pathway architecture for stress to disrupt agency and promote habit

A diencephalic circuit in rats for opioid analgesia but not positive reinforcement

NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Germline Elongator mutations in Sonic Hedgehog medulloblastoma

Development and validation of a high throughput SARS-CoV-2 whole genome sequencing workflow in a clinical laboratory

Impact of the COVID-19 nonpharmaceutical interventions on influenza and other respiratory viral infections in New Zealand

Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Defining a research agenda for environmental wastewater surveillance of pathogens

Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling: role of the ubiquitin proteasome system

Childhood nephrotic syndrome and the clinical profile of thromboembolism: a systematic review and meta-analysis

Assessing non-Mendelian inheritance in inherited axonopathies

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