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Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain

Chen et al. show that subtypes of immune cells in prenatal human brain promote angiogenesis in the germinal matrix. Conversely, in preterm infants, proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage.

Jiapei Chen
Elizabeth E. Crouch
Eric J. Huang
ResearchOpen Access30 Sept 2024
Nature Neuroscience

Volume: 27, P: 2115-2129
Profiling human brain vascular cells using single-cell transcriptomics and organoids

A protocol extension describing the purification of prenatal human brain endothelial and mural cells with FACS and their utilization in downstream applications, including cell culture, organoid transplantation and single-cell transcriptomics.

Elizabeth E. Crouch
Loukas N. Diafos
Eric J. Huang
Protocols15 Dec 2023
Nature Protocols

Volume: 19, P: 603-628

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Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain

Profiling human brain vascular cells using single-cell transcriptomics and organoids

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