Nature Search

The impact of obstructive sleep apnea and heart rate on arterial stiffness: results from the Tokyo Sleep Heart Study

Junya Kani
Kazuki Shiina
Kazuhiro Satomi
ResearchOpen Access22 Aug 2025
Hypertension Research

Volume: 48, P: 2792-2800
Concurrent Presence of Metabolic Syndrome in Obstructive Sleep Apnea Syndrome Exacerbates the Cardiovascular Risk: A Sleep Clinic Cohort Study

Kazuki Shiina
Hirofumi Tomiyama
Akira Yamashina
Research01 Jun 2006
Hypertension Research

Volume: 29, P: 433-441
Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study

Masato Kajikawa
Tatsuya Maruhashi
Yukihito Higashi
ResearchOpen Access15 Jul 2019
Scientific Reports

Volume: 9, P: 1-7
Relationship between Arterial Stiffness and the Risk of Coronary Artery Disease in Subjects with and without Metabolic Syndrome

Yutaka Koji
Hirofumi Tomiyama
Akira Yamashina
Research01 Mar 2007
Hypertension Research

Volume: 30, P: 243-247
The Effects of Changes in the Metabolic Syndrome Detection Status on Arterial Stiffening: A Prospective Study

Hirofumi Tomiyama
Yoji Hirayama
Akira Yamashina
Research01 Sept 2006
Hypertension Research

Volume: 29, P: 673-678
Overweight Body Mass Index Classification Modifies Arterial Stiffening Associated with Weight Gain in Healthy Middle-Aged Japanese Men

Jiko Yamada
Hirofumi Tomiyama
Akira Yamashina
Research01 Jun 2008
Hypertension Research

Volume: 31, P: 1087-1092
Blood pressure reduction with empagliflozin in Japanese patients with type 2 diabetes and cardiovascular diseases: a post-hoc sub-analysis of the placebo-controlled randomized EMBLEM trial

Atsushi Tanaka
Michio Shimabukuro
Kunio Yufu
Research24 May 2024
Hypertension Research

Volume: 47, P: 2295-2302
Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts

Allogenic induced pluripotent stem cell-derived cardiomyocytes transplanted directly into infarcted cynomolgus monkey hearts show electrical coupling with host cardiomyocytes improve cardiac contractile function after mild immunosuppression.

Yuji Shiba
Toshihito Gomibuchi
Uichi Ikeda
Research10 Oct 2016
Nature

Volume: 538, P: 388-391
Canagliflozin independently reduced plasma volume from conventional diuretics in patients with type 2 diabetes and chronic heart failure: a subanalysis of the CANDLE trial

Kazuki Shiina
Hirofumi Tomiyama
Akiomi Yoshihisa
Research15 Nov 2022
Hypertension Research

Volume: 46, P: 495-506
Differential effect of a xanthine oxidase inhibitor on arterial stiffness and carotid atherosclerosis: a subanalysis of the PRIZE study

Xanthine oxidase (XO) inhibition by febuxostat, rather than the effect of lowering hyperuricemia, may have directly contributed to the improvement of arterial stiffness in the present study. Plausible explanations of this beneficial effect are proposed as the counter action via XO inhibition to macrophage adventitial infiltration, vascular cell hypertrophy, and proliferation of vascular smooth muscle cell and vascular wall connective tissues or endothelial dysfunction.

Kazuki Shiina
Hirofumi Tomiyama
Koichi Node
Research15 Feb 2022
Hypertension Research

Volume: 45, P: 602-611
Concomitant existence and interaction of cardiovascular abnormalities in obstructive sleep apnea subjects with normal clinic blood pressure

Hirofumi Tomiyama
Yoshifumi Takata
Akira Yamashina
Research23 Jan 2009
Hypertension Research

Volume: 32, P: 201-206
Central blood pressure: a powerful predictor of the development of hypertension

Hirofumi Tomiyama
Michael F O'rourke
Akira Yamashina
Research09 Aug 2012
Hypertension Research

Volume: 36, P: 19-24
Association of blood pressure levels with the effects of alcohol intake on the vasculature in Japanese men

Chisa Matsumoto
Hirofumi Tomiyama
Akira Yamashina
Research16 Jan 2009
Hypertension Research

Volume: 32, P: 127-132
Heart Rate Elevation Precedes the Development of Metabolic Syndrome in Japanese Men: A Prospective Study

Hirofumi Tomiyama
Jiko Yamada
Akira Yamashina
Research01 May 2007
Hypertension Research

Volume: 30, P: 417-426
Who benefits from the blood pressure-lowering effects of SGLT2 inhibitors in patients with type 2 diabetes mellitus and chronic kidney disease? — Obese or non-obese?

Kazuki Shiina
Comments & Opinion15 Dec 2023
Hypertension Research

Volume: 47, P: 681-682
Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study

Kenya Kusunose
Hisako Yoshida
Mikiko Kagiyama
ResearchOpen Access17 Oct 2021
Hypertension Research

Volume: 45, P: 106-115
Differences in longitudinal associations of cardiovascular risk factors with arterial stiffness and pressure wave reflection in middle-aged Japanese men

Masatsune Fujii
Hirofumi Tomiyama
Taishiro Chikamori
Research28 Jul 2020
Hypertension Research

Volume: 44, P: 98-106
Usefulness of the SAGE score to predict elevated values of brachial-ankle pulse wave velocity in Japanese subjects with hypertension

Hirofumi Tomiyama
Charalambos Vlachopoulos
Shin-ichiro Ueda
Research26 May 2020
Hypertension Research

Volume: 43, P: 1284-1292
Obstructive sleep apnea -related hypertension: a review of the literature and clinical management strategy

Clinical characteristics and management strategy of OSA-related hypertension. OSA: obstructive sleep apnea, BP: blood pressure, ABPM: ambulatory blood pressure monitoring, CPAP: continuous positive airway pressure, LVH: left ventricular hypertrophy, ARB: angiotensin II receptor blocker, SGLT2i: Sodium-glucose cotransporter 2 inhibitors, ARNI: angiotensin receptor-neprilysin inhibitor, CCB: calcium channel blocker, GIP/GLP-1 RA: glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonist.

Kazuki Shiina
ReviewsOpen Access29 Aug 2024
Hypertension Research

Volume: 47, P: 3085-3098
Modulation of blood pressure-lowering effects of dark chocolate according to an insulin sensitivity-randomized crossover study

Chisa Matsumoto
Hirofumi Tomiyama
Akira Yamshina
Correspondence20 Jan 2020
Hypertension Research

Volume: 43, P: 575-578
Gender difference in the effects of cacao polyphenols on blood pressure and glucose/lipid metabolism in prediabetic subjects: a double-blinded, randomized, placebo-controlled crossover trial

Kazuki Shiina
Hirofumi Tomiyama
Akira Yamashina
Correspondence17 Jan 2019
Hypertension Research

Volume: 42, P: 1083-1085
New approach to arterial stiffness: BP-independent local carotid stiffness

Kazuki Shiina
Hirofumi Tomiyama
Comments & Opinion17 Aug 2017
Hypertension Research

Volume: 40, P: 910-911
Factors associated with carotid intima-media thickness progression in patients with asymptomatic hyperuricemia: insights from the PRIZE study

Yuichi Saito
Atsushi Tanaka
Mikiko Kagiyama
ResearchOpen Access05 Jul 2023
Scientific Reports

Volume: 13, P: 1-10

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