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Showing 1–11 of 11 results
Advanced filters: Author: Kazuto Saiki Clear advanced filters

  • A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

    • Ho Namkoong
    • Ryuya Edahiro
    • Yukinori Okada
    ResearchOpen Access
    Nature
    Volume: 609, P: 754-760

  • A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

    • Ryuya Edahiro
    • Go Sato
    • Yukinori Okada
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 1905-1921

  • Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

    • Qingbo S. Wang
    • Ryuya Edahiro
    • Yukinori Okada
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

    • Noah Sasa
    • Shohei Kojima
    • Yukinori Okada
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 65-79

  • The origin of the dichotomy between the lunar nearside and farside is unclear. Analysis of spectral reflectance data from the Kaguya lunar orbiter indicates a systematic difference in the degree of differentiation in the oldest lunar crustal terrains, linking the lunar dichotomy to crystallization of the magma ocean.

    • Makiko Ohtake
    • Hiroshi Takeda
    • Paul G. Lucey
    Research
    Nature Geoscience
    Volume: 5, P: 384-388

  • The nearside and farside of the Moon are compositionally distinct. The detection of low-calcium pyroxene around large impact basins suggests that the huge Procellarum basin on the nearside may be an ancient impact structure and a relic scar of the violent collision that produced the lunar dichotomy.

    • Ryosuke Nakamura
    • Satoru Yamamoto
    • Kazuto Saiki
    Research
    Nature Geoscience
    Volume: 5, P: 775-778

  • Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

    • Ryuya Edahiro
    • Yuya Shirai
    • Yukinori Okada
    ResearchOpen Access
    Nature Genetics
    Volume: 55, P: 753-767

  • Structural changes induced by thermal denaturation and renaturation of a double-helical polysaccharide xanthan in acidic and basic solutions were investigated mainly by light scattering measurements and circular dichroism spectroscopy. In acidic solution, the renatured components were almost the same as those in native components, while small amounts of aggregates and a hairpin structure were produced via denaturation and renaturation processes. In basic solution, the double helices were dissociated upon heating into the single coils, and high molar mass sample produced a hairpin structure after subsequent renaturation.

    • Yasuhiro Matsuda
    • Ryoga Saiki
    • Kazuto Yoshiba
    Research
    Polymer Journal
    Volume: 56, P: 629-637

  • It has long been thought that the lunar highland crust was formed by the crystallization and floatation of plagioclase from a global magma ocean, but the exact mechanism by which such a crust formed remains debated. Data from the Japanese SELENE spacecraft are now used to produce a clear and high spatial resolution view of the composition of the lunar crust. The existence of widely distributed crustal rocks with compositions approaching 100 per cent (by volume) plagioclase is revealed.

    • Makiko Ohtake
    • Tsuneo Matsunaga
    • Jean-Luc Josset
    Research
    Nature
    Volume: 461, P: 236-240