The aging myopathy is characterized by diastolic dysfunction of unknown aetiology. Rota et al. show that increased late Na+ current (INaL) underlies diastolic dysfunction in the aged heart, and that inhibiting INaLimproves diastolic indices and corrects the kinetics of cardiomyocyte contraction and relaxation in aged mice.
- Sergio Signore
- Andrea Sorrentino
- Marcello Rota