Fujita, Ochmachi et al combine a DNA origami approach with darkfield microscopy and AFM to study conformational changes in muscle myosin. They generate DNA origami-based thick filaments that enable the direct visualisation of mechanistic details of myosins during force generation under geometric conditions that resemble those in muscle.
- Keisuke Fujita
- Masashi Ohmachi
- Mitsuhiro Iwaki
