Nature Search

In vivo mechano-tissue engineering by hydrogels capable of transmitting intercellular mechanical stress

Here, authors develop a ligand-free strategy to mechanically activate cells in a hydrogel by utilizing a biorthogonal click reaction to form a covalent bond between azide-modified cellular integrins and the hydrogel. They then apply this strategy in vivo to show that the transmittance of mechanical stress using the hydrogel system promotes regeneration of skeletal muscle.

Natsumi Ueda
Hayato Okazaki
Koji Nagahama
ResearchOpen Access15 Oct 2025
Nature Communications

Volume: 16, P: 1-21
Chemical inhibition of stomatal differentiation by perturbation of the master-regulatory bHLH heterodimer via an ACT-Like domain

This study reports Stomidazolone, a doubly-sulfonylated imidazolone that inhibits stomatal differentiation by binding to the ACT-Like domain of MUTE, disrupting its interaction with the bHLH partner SCREAM, which expands the chemical toolkit for manipulating bHLH-ACTL protein interactions, offering new avenues for controlling plant development.

Ayami Nakagawa
Krishna Mohan Sepuru
Keiko U. Torii
ResearchOpen Access23 Oct 2024
Nature Communications

Volume: 15, P: 1-17
Competitive binding of antagonistic peptides fine-tunes stomatal patterning

An investigation of the molecular mechanism of stomatal development and patterning finds an unexpected signalling mechanism: two signalling peptides (STOMAGEN, a positive regulator of stomatal development; and EPF2, a negative regulator of this process) use the same receptor kinase, ERECTA, to fine-tune stomatal development.

Jin Suk Lee
Marketa Hnilova
Keiko U. Torii
Research17 Jun 2015
Nature

Volume: 522, P: 439-443
Cryptic bioactivity capacitated by synthetic hybrid plant peptides

Peptide hormones play versatile roles in plant development and environmental responses. Here the authors report the engineering of a synthetic plant peptide that acts on meristems through interaction with both the CLV1 and TDR/PXY receptors ofArabidopsis thaliana.

Yuki Hirakawa
Hidefumi Shinohara
Naoyuki Uchida
ResearchOpen Access06 Feb 2017
Nature Communications

Volume: 8, P: 1-7
Direct attenuation of Arabidopsis ERECTA signalling by a pair of U-box E3 ligases

PUB30/31 ensure the optimal signalling output of ERECTA for proper plant growth and stomatal development. A heterodimeric partner BAK1 is a kinase and a scaffold that activates PUB30/31, which in turn ubiquitinate ligand-activated ERECTA for degradation.

Liangliang Chen
Alicia M. Cochran
Keiko U. Torii
ResearchOpen Access20 Dec 2022
Nature Plants

Volume: 9, P: 112-127
Termination of asymmetric cell division and differentiation of stomata

Production of stomata, the gas-exchange structure in plants, requires asymmetric cell division and cell type differentiation in an orderly manner. Identification of a key switch gene for the fate transition of stomatal precursor cells revealed a compelling view that consecutive actions of three closely related bHLH proteins control stomatal differentiation, a mechanism strikingly similar to cell-type differentiation in animals.

Lynn Jo Pillitteri
Daniel B. Sloan
Keiko U. Torii
Research20 Dec 2006
Nature

Volume: 445, P: 501-505
Author Correction: Phosphocode-dependent functional dichotomy of a common co-receptor in plant signalling

Artemis Perraki
Thomas A. DeFalco
Cyril Zipfel
Amendments and Corrections17 Oct 2018
Nature

Volume: 563, P: E30
Dynamic chromatin accessibility deploys heterotypic cis/trans-acting factors driving stomatal cell-fate commitment

Chromatin accessibility dynamics profiling throughout the development of the stomatal lineage uncovers a crucial role for heterotypic cis- and trans-acting factors. These drive cell-fate commitment during specialized cell-type differentiation.

Eun-Deok Kim
Michael W. Dorrity
Keiko U. Torii
ResearchOpen Access15 Dec 2022
Nature Plants

Volume: 8, P: 1453-1466
GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region

Here, the authors identify six risk SNPs for systemic sclerosis by performing GWAS on Japanese patients and meta-analyzing Japanese and European GWAS datasets. Downstream analyses indicate that B cells contribute to pathogenesis.

Yuki Ishikawa
Nao Tanaka
Chikashi Terao
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-16
Bipartite anchoring of SCREAM enforces stomatal initiation by coupling MAP kinases to SPEECHLESS

Arabidopsis MPK3 and MPK6 are involved in many biological processes. How do they achieve their signalling specificity? Structural, biochemical and genetic approaches show that the bHLH protein SCREAM acts as a scaffold to recruit downstream substrates during stomatal development.

Aarthi Putarjunan
Jim Ruble
Keiko U. Torii
Research24 Jun 2019
Nature Plants

Volume: 5, P: 742-754
Chemical hijacking of auxin signaling with an engineered auxin–TIR1 pair

A synthetic, orthogonal pair of the plant hormone auxin and its receptor TIR1 was engineered to hijack auxin signaling without interfering with the endogenous system. The synthetic system conclusively demonstrates the role for TIR1 in auxin-induced acid growth.

Naoyuki Uchida
Koji Takahashi
Keiko U Torii
Research22 Jan 2018
Nature Chemical Biology

Volume: 14, P: 299-305
Cargo receptor Surf4 regulates endoplasmic reticulum export of proinsulin in pancreatic β-cells

Surf4 is an ER cargo receptor for proinsulin, facilitating proinsulin export out of the ERES in a cellular model of pancreatic β-cells, with its expression dependent on glucose concentration and Surf4 knockdown impairing insulin secretion.

Keiko Saegusa
Kohichi Matsunaga
Ken Sato
ResearchOpen Access13 May 2022
Communications Biology

Volume: 5, P: 1-12
Rapid and reversible root growth inhibition by TIR1 auxin signalling

Using an innovative combination of microfluidics and live imaging, the authors demonstrate that the inhibition of root growth by auxin happens in seconds—and so does not require transcription—and is dependent on TIR1/AFB receptors.

Matyáš Fendrych
Maria Akhmanova
Jiří Friml
Research25 Jun 2018
Nature Plants

Volume: 4, P: 453-459
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses

On 11 June 2009 the World Health Organization declared that the infections caused by a new strain of influenza A virus closely related to swine viruses had reached pandemic levels. Here, one of the first US isolates of the new swine-origin H1N1 influenza virus (S-OIV) is characterized, as well as several other S-OIV isolates, both in vitro and in vivo.

Yasushi Itoh
Kyoko Shinya
Yoshihiro Kawaoka
Research13 Jul 2009
Nature

Volume: 460, P: 1021-1025
Phosphocode-dependent functional dichotomy of a common co-receptor in plant signalling

The plant receptor kinase co-receptor BAK1 contains phosphosites that are required for immune function but not for brassinosteroid-regulated growth in Arabidopsis thaliana; an additional tyrosine phosphosite may be required for the function of many Arabidopsis receptor kinases.

Artemis Perraki
Thomas A. DeFalco
Cyril Zipfel
Research03 Sept 2018
Nature

Volume: 561, P: 248-252
Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments

Takeru Torii
Wataru Sugimoto
Keiko Kawauchi
ResearchOpen Access25 Nov 2023
Cell Death & Disease

Volume: 14, P: 1-10
Peripheral nerve regeneration following scaffold-free conduit transplant of autologous dermal fibroblasts: a non-randomised safety and feasibility trial

Ikeguchi et al. established nerve conduits from three patients’ dermal fibroblasts using a bioprinter and transplanted them back into the patients’ nerve defects. No adverse events occurred, and the nerves recovered following the transplant.

Ryosuke Ikeguchi
Tomoki Aoyama
Shuichi Matsuda
ResearchOpen Access26 Jan 2024
Communications Medicine

Volume: 4, P: 1-7
Plant synthetic biology for molecular engineering of signalling and development

Jennifer L. Nemhauser
Keiko U. Torii
Reviews02 Mar 2016
Nature Plants

Volume: 2, P: 1-7
Cross-sectional association of equol producing status with aortic calcification in Japanese men aged 40–79 years

Xiao Zhang
Akira Fujiyoshi
Akira Sekikawa
ResearchOpen Access22 Nov 2022
Scientific Reports

Volume: 12, P: 1-8

Search

In vivo mechano-tissue engineering by hydrogels capable of transmitting intercellular mechanical stress

Chemical inhibition of stomatal differentiation by perturbation of the master-regulatory bHLH heterodimer via an ACT-Like domain

Competitive binding of antagonistic peptides fine-tunes stomatal patterning

Cryptic bioactivity capacitated by synthetic hybrid plant peptides

Direct attenuation of Arabidopsis ERECTA signalling by a pair of U-box E3 ligases

Termination of asymmetric cell division and differentiation of stomata

Author Correction: Phosphocode-dependent functional dichotomy of a common co-receptor in plant signalling

Dynamic chromatin accessibility deploys heterotypic cis/trans-acting factors driving stomatal cell-fate commitment

GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region

Bipartite anchoring of SCREAM enforces stomatal initiation by coupling MAP kinases to SPEECHLESS

Chemical hijacking of auxin signaling with an engineered auxin–TIR1 pair

Cargo receptor Surf4 regulates endoplasmic reticulum export of proinsulin in pancreatic β-cells

Rapid and reversible root growth inhibition by TIR1 auxin signalling

In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses

Phosphocode-dependent functional dichotomy of a common co-receptor in plant signalling

Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments

Peripheral nerve regeneration following scaffold-free conduit transplant of autologous dermal fibroblasts: a non-randomised safety and feasibility trial

Plant synthetic biology for molecular engineering of signalling and development

Cross-sectional association of equol producing status with aortic calcification in Japanese men aged 40–79 years

Search

Quick links

Search

Filter By:

Search

Quick links