Nature Search

The neural basis of species-specific defensive behaviour in Peromyscus mice

Visual threat triggers contrasting freeze and escape defensive responses in two species of deer mice as a result of different activation thresholds downstream of the superior colliculus in the dorsal periaqueductal grey.

Felix Baier
Katja Reinhard
Hopi E. Hoekstra
ResearchOpen Access23 Jul 2025
Nature

Volume: 645, P: 439-447
The soluble neurexin-1β ectodomain causes calcium influx and augments dendritic outgrowth and synaptic transmission

Keimpe D. B. Wierda
Trine L. Toft-Bertelsen
Jakob B. Sørensen
ResearchOpen Access22 Oct 2020
Scientific Reports

Volume: 10, P: 1-15
Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer’s disease-relevant brain circuits

This latest research reveals that changes in PSEN2 expression accelerate amyloid build-up, disrupt lysosomal function, and weaken synaptic connections. These findings spotlight PSEN2 as a powerful target for early Alzheimer’s disease intervention.

Anika Perdok
Zoë P. Van Acker
Wim Annaert
ResearchOpen Access29 Nov 2024
Nature Communications

Volume: 15, P: 1-20
Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer

Mossy fiber synapses are key in CA3 microcircuit function. Here, the authors profile the mossy fiber synapse proteome and cell-surface interactome. They uncover a diverse repertoire of cell-surface proteins and identify the receptor IgSF8 as a regulator of CA3 microcircuit connectivity and function.

Nuno Apóstolo
Samuel N. Smukowski
Joris de Wit
ResearchOpen Access14 Oct 2020
Nature Communications

Volume: 11, P: 1-21
Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease

Increased neuronal activity and reduced sleep quality emerge in the early stages of Alzheimer’s disease (AD). Calafate et al. show that the sleep–active hypothalamic MCH system is involved in neuronal homeostasis but fails in the early stages of AD.

Sara Calafate
Gökhan Özturan
Joris de Wit
ResearchOpen Access15 May 2023
Nature Neuroscience

Volume: 26, P: 1021-1031
Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

The molecular mechanism underlying the generation and maintenance of the readily releasable pool composed of primed synaptic vesicles is only partially known. Here the authors show that in mouse primary neurons, Munc13-1 and Munc18-1 stabilize primed synaptic vesicles by preventing NSF-dependent de-priming.

Enqi He
Keimpe Wierda
Matthijs Verhage
ResearchOpen Access21 Jun 2017
Nature Communications

Volume: 8, P: 1-10
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

Liston and colleagues design a gene-delivery system to specifically target astrocytes in the central nervous system to express IL-2 and thereby expand/maintain T_reg cells to suppress neuroinflammation.

Lidia Yshii
Emanuela Pasciuto
Adrian Liston
ResearchOpen Access26 May 2022
Nature Immunology

Volume: 23, P: 878-891
Tau association with synaptic vesicles causes presynaptic dysfunction

Mislocalisation of tau occurs in several neurodegenerative diseases and is thought to contribute to synaptic function. The authors show that presynaptically, tau binds to synaptic vesicles via the N-terminus which contributes to synaptic dysfunction.

Lujia Zhou
Joseph McInnes
Patrik Verstreken
ResearchOpen Access11 May 2017
Nature Communications

Volume: 8, P: 1-13
Corticotropin-releasing factor induces functional and structural synaptic remodelling in acute stress

Dorien Vandael
Keimpe Wierda
Natalia V. Gounko
ResearchOpen Access07 Jul 2021
Translational Psychiatry

Volume: 11, P: 1-12
Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes

Abdulsamie M. Patel
Keimpe Wierda
Catherine M. Verfaillie
ResearchOpen Access21 Aug 2019
Translational Psychiatry

Volume: 9, P: 1-21

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The neural basis of species-specific defensive behaviour in Peromyscus mice

The soluble neurexin-1β ectodomain causes calcium influx and augments dendritic outgrowth and synaptic transmission

Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer’s disease-relevant brain circuits

Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer

Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

Tau association with synaptic vesicles causes presynaptic dysfunction

Corticotropin-releasing factor induces functional and structural synaptic remodelling in acute stress

Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes

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