Catalytic asymmetric cyanation of ketones is a straightforward method to construct tetrasubstituted chiral carbon centers, but for acylsilanes this method has been limited to enzymatic approaches. Here, non-enzymatic catalytic asymmetric cyanation of acylsilanes is accomplished using a chiral Lewis base as an enantioselective catalyst.
- Tagui Nagano
- Akira Matsumoto
- Seijiro Matsubara
