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Nature Cell Biology (1)

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Stem cells

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Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages

Sato et al. demonstrate that IRF2, which negatively regulates interferon signalling, safeguards intestinal stem cells against non-infectious, sterile interferon stress by limiting their differentiation into secretory lineages.

Taku Sato
Shun Ishikawa
Toshiaki Ohteki
Research20 Jul 2020
Nature Cell Biology

Volume: 22, P: 919-926

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Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages

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